Patient demographics and clinical and molecular characteristics of CEBPAwt, CEBPAsm, and CEBPAdm CN-AML cases
| Characteristic . | CEBPAwt (n = 1031) . | CEBPAsm (n = 60) . | P, CEBPAsm vs CEBPAwt . | CEBPAdm (n = 91) . | P, CEBPAdm vs CEBPAwt . | P, CEBPAsm vs CEBPAdm . |
|---|---|---|---|---|---|---|
| Median age, y (range) | 48 (16-60) | 46 (18-60) | .28 | 44 (16-60) | .04* | .66 |
| Sex, n (%) | .79 | .74 | .74 | |||
| Male | 500 (48) | 28 (47) | 46 (51) | |||
| Female | 531 (52) | 32 (53) | 45 (49) | |||
| WBC count, ×109/L | .23 | .062 | .86 | |||
| Median (range) | 28 (0.2-372) | 25 (1.1-345) | 28 (1.5-262) | |||
| Missing | 34 | 1 | 4 | |||
| Platelet count, ×109/L | .77 | < .0001* | < .0001* | |||
| Median (range) | 65 (5-746) | 62 (10-361) | 38 (4-265) | |||
| Missing | 40 | 3 | 4 | |||
| Bone marrow blasts | .83 | .53 | .76 | |||
| Median (range) | 80 (0-100) | 80 (0-97) | 78 (2-100) | |||
| Missing | 80 | 7 | 4 | |||
| Molecular abnormalities | ||||||
| FLT3ITD, n (%) | 347 (33.7) | 18 (30) | 1 | 7 (7.7) | < .0001* | .00015* |
| Missing | 69 | 9 | 5 | |||
| FLT3TKD, n (%) | 95 (9.2) | 4 (6.7) | .81 | 2 (2.2) | .018* | .2 |
| Missing | 48 | 6 | 3 | |||
| NPM1, n (%) | 560 (54.3) | 21 (35) | .018* | 3 (3.3) | 0 | < .0001* |
| Missing | 88 | 10 | 8 |
| Characteristic . | CEBPAwt (n = 1031) . | CEBPAsm (n = 60) . | P, CEBPAsm vs CEBPAwt . | CEBPAdm (n = 91) . | P, CEBPAdm vs CEBPAwt . | P, CEBPAsm vs CEBPAdm . |
|---|---|---|---|---|---|---|
| Median age, y (range) | 48 (16-60) | 46 (18-60) | .28 | 44 (16-60) | .04* | .66 |
| Sex, n (%) | .79 | .74 | .74 | |||
| Male | 500 (48) | 28 (47) | 46 (51) | |||
| Female | 531 (52) | 32 (53) | 45 (49) | |||
| WBC count, ×109/L | .23 | .062 | .86 | |||
| Median (range) | 28 (0.2-372) | 25 (1.1-345) | 28 (1.5-262) | |||
| Missing | 34 | 1 | 4 | |||
| Platelet count, ×109/L | .77 | < .0001* | < .0001* | |||
| Median (range) | 65 (5-746) | 62 (10-361) | 38 (4-265) | |||
| Missing | 40 | 3 | 4 | |||
| Bone marrow blasts | .83 | .53 | .76 | |||
| Median (range) | 80 (0-100) | 80 (0-97) | 78 (2-100) | |||
| Missing | 80 | 7 | 4 | |||
| Molecular abnormalities | ||||||
| FLT3ITD, n (%) | 347 (33.7) | 18 (30) | 1 | 7 (7.7) | < .0001* | .00015* |
| Missing | 69 | 9 | 5 | |||
| FLT3TKD, n (%) | 95 (9.2) | 4 (6.7) | .81 | 2 (2.2) | .018* | .2 |
| Missing | 48 | 6 | 3 | |||
| NPM1, n (%) | 560 (54.3) | 21 (35) | .018* | 3 (3.3) | 0 | < .0001* |
| Missing | 88 | 10 | 8 |
Number of cases (percentage), median, range, or missing values are indicated.
WBC indicates white blood cell.
P < .05 computed using the Mann-Whitney U test (continuous variables) and 2-sided Fisher exact test (categorical variables).