Table 6 Literature overview of... | American Society of Hematology

Table 6

Literature overview of immunohistochemical studies for subtyping in systemic amyloidosis

	Bergesio (2007)¹⁴	Kebbel (2006)⁸	Gallo (1986)¹⁶	Strege (1998)⁵	Collins (2009)¹⁵	Novak (2004)¹⁷	Current study
No. of patients	373	121	50	43	40	36	117
Biopsy sites	Kidney*	All	Kidney†	Autopsy series	Kidney, heart‡	Kidney	All§
Most common types	AL, AA	AL, AA	AA, AL	AA, TTR	AL	AL	AL, TTR
Unclassified, %	7	10	12	2	15	33	6
Clinical data	Clinical, laboratory, bone marrow, family history, genotyping	Clinical picture	Laboratory, bone marrow	Autopsy reports	Laboratory	Laboratory	Clinical laboratory, bone marrow, family history, genotyping

	Bergesio (2007)¹⁴	Kebbel (2006)⁸	Gallo (1986)¹⁶	Strege (1998)⁵	Collins (2009)¹⁵	Novak (2004)¹⁷	Current study
No. of patients	373	121	50	43	40	36	117
Biopsy sites	Kidney*	All	Kidney†	Autopsy series	Kidney, heart‡	Kidney	All§
Most common types	AL, AA	AL, AA	AA, AL	AA, TTR	AL	AL	AL, TTR
Unclassified, %	7	10	12	2	15	33	6
Clinical data	Clinical, laboratory, bone marrow, family history, genotyping	Clinical picture	Laboratory, bone marrow	Autopsy reports	Laboratory	Laboratory	Clinical laboratory, bone marrow, family history, genotyping

Although this study evaluated patients with renal amyloidosis, only 315 patients underwent a kidney biopsy; the remaining patients were diagnosed by a different organ biopsy. This was a multicenter study; only 30 of the 45 participating centers used routinely κ and λ antibodies in all renal biopsies.

†

Although all biopsy sites were admitted in the study, renal biopsies prevailed by far with 37 of 50 cases.

‡

This study included a series of 17 cardiac and 23 renal biopsies.

Only 14 renal biopsies included.

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