Comparison of clinical and laboratory features between AML patients with and without the DNMT3A mutation
| Variable . | Total (n = 500) . | DNMT3A-mutated (n = 70, 14%) . | DNMT3A-wild (n = 430, 86%) . | P . |
|---|---|---|---|---|
| Sex, n | .7961 | |||
| Male | 285 | 41 | 244 | |
| Female | 215 | 29 | 186 | |
| Median age, y (range) | 51 (15-90) | 61 (16-87) | 49 (15-90) | < .0001 |
| Laboratory data, median (range) | ||||
| WBCs, /μL | 19 075 (120-627 800) | 32 490 (650-340 400) | 15 940 (120-627 800) | .0018 |
| Hemoglobin, g/dL | 8 (2.9-16.2) | 8.7 (3.2-12) | 7.9 (2.9-16.2) | .0675 |
| Platelets, × 1000/μL | 42 (2-802) | 57 (10-436) | 39 (2-802) | .0001 |
| Blasts, /μL | 7401 (0-456 725) | 19 030 (111-283 212) | 6263 (0-456 725) | .0012 |
| Lactase dehydrogenase, U/L | 889 (206-15 000) | 1064 (250-8116) | 832 (206-15 000) | .0883 |
| FAB, n (%) | < .0001 | |||
| M0 | 10 | 2 (20) | 8 (80) | .6375 |
| M1 | 112 | 14 (12.5) | 98 (87.5) | .7572 |
| M2 | 171 | 13 (7.6) | 158 (92.4) | .0027 |
| M3 | 38 | 0 (0) | 38 (100) | .0056 |
| M4 | 124 | 28 (22.6) | 96 (77.4) | .0026 |
| M5 | 24 | 12 (50) | 12 (50) | < .0001 |
| M6 | 12 | 0 (0) | 12 (100) | .3889 |
| Undetermined | 9 | 1 (11.1) | 8 (88.9) | > .9999 |
| Variable . | Total (n = 500) . | DNMT3A-mutated (n = 70, 14%) . | DNMT3A-wild (n = 430, 86%) . | P . |
|---|---|---|---|---|
| Sex, n | .7961 | |||
| Male | 285 | 41 | 244 | |
| Female | 215 | 29 | 186 | |
| Median age, y (range) | 51 (15-90) | 61 (16-87) | 49 (15-90) | < .0001 |
| Laboratory data, median (range) | ||||
| WBCs, /μL | 19 075 (120-627 800) | 32 490 (650-340 400) | 15 940 (120-627 800) | .0018 |
| Hemoglobin, g/dL | 8 (2.9-16.2) | 8.7 (3.2-12) | 7.9 (2.9-16.2) | .0675 |
| Platelets, × 1000/μL | 42 (2-802) | 57 (10-436) | 39 (2-802) | .0001 |
| Blasts, /μL | 7401 (0-456 725) | 19 030 (111-283 212) | 6263 (0-456 725) | .0012 |
| Lactase dehydrogenase, U/L | 889 (206-15 000) | 1064 (250-8116) | 832 (206-15 000) | .0883 |
| FAB, n (%) | < .0001 | |||
| M0 | 10 | 2 (20) | 8 (80) | .6375 |
| M1 | 112 | 14 (12.5) | 98 (87.5) | .7572 |
| M2 | 171 | 13 (7.6) | 158 (92.4) | .0027 |
| M3 | 38 | 0 (0) | 38 (100) | .0056 |
| M4 | 124 | 28 (22.6) | 96 (77.4) | .0026 |
| M5 | 24 | 12 (50) | 12 (50) | < .0001 |
| M6 | 12 | 0 (0) | 12 (100) | .3889 |
| Undetermined | 9 | 1 (11.1) | 8 (88.9) | > .9999 |