Distribution of other mutations
| . | Available, n . | Mutated total, n (%) . | Mutated in RUNX1mut, n/N (%) . | Mutated in RUNX1wt, n/N (%) . | P . |
|---|---|---|---|---|---|
| CEBPA | 437 | 41 (9.4) | 2/147 (1.4) | 39/290 (13.4) | < .001* |
| NPM1 | 449 | 58 (12.9) | 1/147 (0.7) | 57/302 (18.9) | < .001* |
| MLL-PTD | 449 | 77 (17.1) | 29/147 (19.7) | 48/302 (15.9) | .351 |
| FLT3-ITD | 449 | 73 (16.3) | 24/147 (16.3) | 49/302 (16.2) | .999 |
| FLT3-TKD | 446 | 18 (4.0) | 9/145 (6.2) | 9/301 (3.0) | .125 |
| NRAS | 446 | 60 (13.5) | 14/147 (9.5) | 46/299 (15.4) | .104 |
| JAK2 | 377 | 9 (2.4) | 0/127 | 9/250 (3.6) | .032* |
| . | Available, n . | Mutated total, n (%) . | Mutated in RUNX1mut, n/N (%) . | Mutated in RUNX1wt, n/N (%) . | P . |
|---|---|---|---|---|---|
| CEBPA | 437 | 41 (9.4) | 2/147 (1.4) | 39/290 (13.4) | < .001* |
| NPM1 | 449 | 58 (12.9) | 1/147 (0.7) | 57/302 (18.9) | < .001* |
| MLL-PTD | 449 | 77 (17.1) | 29/147 (19.7) | 48/302 (15.9) | .351 |
| FLT3-ITD | 449 | 73 (16.3) | 24/147 (16.3) | 49/302 (16.2) | .999 |
| FLT3-TKD | 446 | 18 (4.0) | 9/145 (6.2) | 9/301 (3.0) | .125 |
| NRAS | 446 | 60 (13.5) | 14/147 (9.5) | 46/299 (15.4) | .104 |
| JAK2 | 377 | 9 (2.4) | 0/127 | 9/250 (3.6) | .032* |
The respective marker occurs less frequently in RUNX1-mutated AML.