Findings at diagnosis and during the course of TAM were significantly associated with early death and the progression to leukemia (univariate analysis)
| Variable . | Total (n = 66) . | Early death (n = 16) . | P . | Progressed to ML-DS (n = 11) . | P . |
|---|---|---|---|---|---|
| Sex | |||||
| Male, n (%) | 32 (48.5) | 11 (68.8) | 5 (45.5) | ||
| Female, n (%) | 34 (51.5) | 5 (31.3) | .088 | 6 (54.5) | .947 |
| Median gestational age, wk (range) | 37.35 (30.0-40.6) | 34.6 (30.0-38.4) | 38.1 (32.6-40.6) | ||
| Term versus preterm | |||||
| Term (≥ 37 weeks), n (%) | 27 (58.7) | 4 (30.8) | 5 (71.4) | ||
| Preterm (< 37 weeks), n (%) | 19 (41.3) | 9 (69.2) | .021 | 2 (28.6) | .465 |
| Median birth weight, kg (range) | 2.5 (1.4-3.5) | 2.2 (1.6-2.7) | 2.5 (1.6-3.5) | ||
| Not LBW versus LBW | |||||
| Not LBW (≥ 2.5 kg), n (%) | 24 (52.2) | 3 (23.1) | 3 (42.9) | ||
| LBW (< 2.5 kg), n (%) | 22 (47.8) | 10 (76.9) | .025 | 4 (57.1) | .184 |
| Median WBC, ×109/L (range) | 69.4 (7.8-423.0) | 104.3 (33.1-290.8) | 26 (14.6-244.0) | ||
| WBC < 70 × 109/L vs WBC > 70 × 109/L | |||||
| WBC < 70 × 109/L, n (%) | 30 (50.8) | 4 (25.0) | 7 (63.6) | ||
| WBC > 70 × 109/L, n (%) | 29 (49.2) | 12 (75.0) | .020 | 4 (36.4) | .755 |
| Median peripheral blasts, % (range) | 56.0 (4.0-94.0) | 78.0 (8.0-93.0) | .031 | 49.5 (6.0-66.0) | .752 |
| Median AST, IU/L (range) | 61 (16-4341) | 79 (41-3866) | .620 | 51 (16-153) | .553 |
| Median ALT, IU/L (range) | 39 (4-653) | 41 (7-473) | .455 | 12 (4-96) | .615 |
| Median T-Bil mg/dL (range) | 6.3 (0.6-46.0) | 6.06 (2.4-16.5) | .922 | 3.01 (1.82-6.50) | .023 |
| Effusions, n (%) | 16 of 44 (36.4) | 8 of 11 (72.7) | .007 | 1 of 7 (14.3) | .912 |
| Bleeding diatheses, n (%) | 13 of 45 (28.9) | 8 of 12 (66.7) | .001 | 1 of 7 (14.3) | .123 |
| Variable . | Total (n = 66) . | Early death (n = 16) . | P . | Progressed to ML-DS (n = 11) . | P . |
|---|---|---|---|---|---|
| Sex | |||||
| Male, n (%) | 32 (48.5) | 11 (68.8) | 5 (45.5) | ||
| Female, n (%) | 34 (51.5) | 5 (31.3) | .088 | 6 (54.5) | .947 |
| Median gestational age, wk (range) | 37.35 (30.0-40.6) | 34.6 (30.0-38.4) | 38.1 (32.6-40.6) | ||
| Term versus preterm | |||||
| Term (≥ 37 weeks), n (%) | 27 (58.7) | 4 (30.8) | 5 (71.4) | ||
| Preterm (< 37 weeks), n (%) | 19 (41.3) | 9 (69.2) | .021 | 2 (28.6) | .465 |
| Median birth weight, kg (range) | 2.5 (1.4-3.5) | 2.2 (1.6-2.7) | 2.5 (1.6-3.5) | ||
| Not LBW versus LBW | |||||
| Not LBW (≥ 2.5 kg), n (%) | 24 (52.2) | 3 (23.1) | 3 (42.9) | ||
| LBW (< 2.5 kg), n (%) | 22 (47.8) | 10 (76.9) | .025 | 4 (57.1) | .184 |
| Median WBC, ×109/L (range) | 69.4 (7.8-423.0) | 104.3 (33.1-290.8) | 26 (14.6-244.0) | ||
| WBC < 70 × 109/L vs WBC > 70 × 109/L | |||||
| WBC < 70 × 109/L, n (%) | 30 (50.8) | 4 (25.0) | 7 (63.6) | ||
| WBC > 70 × 109/L, n (%) | 29 (49.2) | 12 (75.0) | .020 | 4 (36.4) | .755 |
| Median peripheral blasts, % (range) | 56.0 (4.0-94.0) | 78.0 (8.0-93.0) | .031 | 49.5 (6.0-66.0) | .752 |
| Median AST, IU/L (range) | 61 (16-4341) | 79 (41-3866) | .620 | 51 (16-153) | .553 |
| Median ALT, IU/L (range) | 39 (4-653) | 41 (7-473) | .455 | 12 (4-96) | .615 |
| Median T-Bil mg/dL (range) | 6.3 (0.6-46.0) | 6.06 (2.4-16.5) | .922 | 3.01 (1.82-6.50) | .023 |
| Effusions, n (%) | 16 of 44 (36.4) | 8 of 11 (72.7) | .007 | 1 of 7 (14.3) | .912 |
| Bleeding diatheses, n (%) | 13 of 45 (28.9) | 8 of 12 (66.7) | .001 | 1 of 7 (14.3) | .123 |
Some clinical data were not available. We defined the number of patients for whom clinical data was available as (n).
LBW indicates low birth weight; AST, aspartate transaminase; ALT, alanine transaminase; and T-Bil, total bilirubin.