Interdependency of distinct signaling pathways
| Protein . | Substrate . | Action . |
|---|---|---|
| JAK2 | STATs | Signaling initiation |
| MAPK | Signaling initiation | |
| PI3K | Signaling initiation | |
| IκB | Degradation (phosphorylation) | |
| PDK1 | PKB | Activation (phosphorylation) |
| IKKβ | Activation (phosphorylation) | |
| RAS | RAF | Activation (phosphorylation) |
| PI3K | Activation | |
| PP2A | IKK | Inhibition (negative feedback) |
| PKB | Inhibition (negative feedback) | |
| SOCS1 | STAT5 | Inhibition (negative feedback) |
| NF-κB | Inhibition (negative feedback) | |
| PIAS1 | JAK2 | Inhibition (negative feedback) |
| RelA | Inhibition DNA binding | |
| PI3K | PKB | Activation (indirect) |
| NF-κB | Activation (phosphorylation) | |
| PKB | mTORC1 | Activation (phosphorylation and indirect) |
| TSC2 | Inhibition (phosphorylation) | |
| RelA | Enhanced activity (phosphorylation) | |
| IKKβ | Activation (indirect) | |
| p38 MAPK | NF-κB | Regulation DNA binding |
| ERK | TSC2 | Inhibition (phosphorylation) |
| NF-κB | SOCS1 | Increased production |
| STAT5 | NF-κB | Activation (phosphorylation) |
| IKKβ | IκBα | Degradation (phosphorylation) |
| TSC1 | Inhibition (phosphorylation) |
| Protein . | Substrate . | Action . |
|---|---|---|
| JAK2 | STATs | Signaling initiation |
| MAPK | Signaling initiation | |
| PI3K | Signaling initiation | |
| IκB | Degradation (phosphorylation) | |
| PDK1 | PKB | Activation (phosphorylation) |
| IKKβ | Activation (phosphorylation) | |
| RAS | RAF | Activation (phosphorylation) |
| PI3K | Activation | |
| PP2A | IKK | Inhibition (negative feedback) |
| PKB | Inhibition (negative feedback) | |
| SOCS1 | STAT5 | Inhibition (negative feedback) |
| NF-κB | Inhibition (negative feedback) | |
| PIAS1 | JAK2 | Inhibition (negative feedback) |
| RelA | Inhibition DNA binding | |
| PI3K | PKB | Activation (indirect) |
| NF-κB | Activation (phosphorylation) | |
| PKB | mTORC1 | Activation (phosphorylation and indirect) |
| TSC2 | Inhibition (phosphorylation) | |
| RelA | Enhanced activity (phosphorylation) | |
| IKKβ | Activation (indirect) | |
| p38 MAPK | NF-κB | Regulation DNA binding |
| ERK | TSC2 | Inhibition (phosphorylation) |
| NF-κB | SOCS1 | Increased production |
| STAT5 | NF-κB | Activation (phosphorylation) |
| IKKβ | IκBα | Degradation (phosphorylation) |
| TSC1 | Inhibition (phosphorylation) |
Although the various signaling cascades regulated by the GM-CSF receptor are often regarded as separate entities, they are actually interrelated, sharing proteins regulating their activation or inhibition, or even directly influencing each other. Proteins involved in more than 1 signaling cascade are listed, together with the proteins they regulate and the actions they express toward them. If 1 of the regulated proteins is regarded as a principle target, this protein is underlined.