The 21 genes selected for the gene-expression study of Churg-Strauss syndrome–associated vasculitic lesions
| Gene . | Alternate name . | Gene definition . |
|---|---|---|
| IL-25/IL-17RB pathway (n = 6) | ||
| IL-25 | IL-17E, IL-25, IL17E | interleukin 25 |
| IL-17RB | CRL4, EVI27, IL17BR, IL17RH1, MGC5245 | interleukin 17 receptor B |
| TRAF6 | MGC:3310, RNF85 | TNF receptor-associated factor 6 |
| SOCS3 | ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3 | suppressor of cytokine signaling 3 |
| MAPK14 | RP1–179N16.5, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 |
| JunB | AP-1 | jun B proto-oncogene |
| Th2 lineage (n = 5) | ||
| GATA-3 | HDR, MGC2346, MGC5199, MGC5445 | GATA binding protein 3 |
| IL-4 | BCGF-1, BCGF1, BSF1 | interleukin 4 |
| IL-5 | EDF, IL-5, TRF | interleukin 5 |
| IL-10 | CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF | interleukin 10 |
| IL-13 | ALRH, BHR1, IL-13, MGC116786, MGC116788 | interleukin 13 |
| Eosinophil and lymphocytes chemokines (n = 10) | ||
| CXCL12 | PBSF, SCYB12, SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, TLSF-a, TLSF-b, TPAR1 | chemokine (C-X-C motif) ligand 12 |
| CXCR4 | CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
| CCL8 | HC14, MCP-2, MCP2, SCYA10, SCYA8 | chemokine (C-C motif) ligand 8 |
| CCR2 | CC-CKR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, FLJ78302, MCP-1-R | chemokine (C-C motif) receptor 2 |
| IL-8 | CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1 | interleukin 8 |
| CXCR2 | CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB | chemokine (C-X-C motif) receptor 2 |
| CCL4 | ACT2, AT744.1, G-26, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 | chemokine (C-C motif) ligand 4 |
| CCR5 | CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, FLJ78003, IDDM22 | chemokine (C-C motif) receptor 5 |
| CCL2 | GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1 | chemokine (C-C motif) ligand 2 |
| CCR3 | CC-CKR-3, CD193, CKR3, CMKBR3, MGC102841 | chemokine (C-C motif) receptor 3 |
| Gene . | Alternate name . | Gene definition . |
|---|---|---|
| IL-25/IL-17RB pathway (n = 6) | ||
| IL-25 | IL-17E, IL-25, IL17E | interleukin 25 |
| IL-17RB | CRL4, EVI27, IL17BR, IL17RH1, MGC5245 | interleukin 17 receptor B |
| TRAF6 | MGC:3310, RNF85 | TNF receptor-associated factor 6 |
| SOCS3 | ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3 | suppressor of cytokine signaling 3 |
| MAPK14 | RP1–179N16.5, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 |
| JunB | AP-1 | jun B proto-oncogene |
| Th2 lineage (n = 5) | ||
| GATA-3 | HDR, MGC2346, MGC5199, MGC5445 | GATA binding protein 3 |
| IL-4 | BCGF-1, BCGF1, BSF1 | interleukin 4 |
| IL-5 | EDF, IL-5, TRF | interleukin 5 |
| IL-10 | CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF | interleukin 10 |
| IL-13 | ALRH, BHR1, IL-13, MGC116786, MGC116788 | interleukin 13 |
| Eosinophil and lymphocytes chemokines (n = 10) | ||
| CXCL12 | PBSF, SCYB12, SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, TLSF-a, TLSF-b, TPAR1 | chemokine (C-X-C motif) ligand 12 |
| CXCR4 | CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
| CCL8 | HC14, MCP-2, MCP2, SCYA10, SCYA8 | chemokine (C-C motif) ligand 8 |
| CCR2 | CC-CKR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, FLJ78302, MCP-1-R | chemokine (C-C motif) receptor 2 |
| IL-8 | CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1 | interleukin 8 |
| CXCR2 | CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB | chemokine (C-X-C motif) receptor 2 |
| CCL4 | ACT2, AT744.1, G-26, LAG1, MIP-1-beta, MIP1B, MIP1B1, SCYA2, SCYA4 | chemokine (C-C motif) ligand 4 |
| CCR5 | CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5, FLJ78003, IDDM22 | chemokine (C-C motif) receptor 5 |
| CCL2 | GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1 | chemokine (C-C motif) ligand 2 |
| CCR3 | CC-CKR-3, CD193, CKR3, CMKBR3, MGC102841 | chemokine (C-C motif) receptor 3 |