Genetic characteristics for the subset of cytogenetically abnormal patients (n = 1058)
| Characteristics . | MK−, n (%) . | MK+, n (%) . | P . |
|---|---|---|---|
| Genetic group | |||
| Risk category* | |||
| Intermediate | 453 (61) | 5 (2) | < .0001 |
| Adverse | 286 (39) | 314 (98) | |
| Cytogenetic abnormalities | |||
| t(9;11) | 55 (7) | 0 (0) | < .0001 |
| t(v;11)(v;q23) | 54 (7) | 7 (2) | .0008 |
| t(6;9) | 16 (2) | 3 (1) | .21 |
| inv(3) or t(3;3) | 11 (2) | 34 (11) | < .0001 |
| −5 or 5q− | 61 (8) | 174 (55) | < .0001 |
| −7 | 42 (6) | 142 (45) | < .0001 |
| 7q− | 54 (7) | 54 (17) | < .0001 |
| +8 or +8q | 205 (28) | 45 (14) | < .0001 |
| +11 or +11q | 37 (5) | 20 (6) | .46 |
| abnl(12p) | 45 (6) | 77 (24) | < .0001 |
| +13 or +13q | 33 (5) | 10 (3) | .40 |
| abnl(17p) | 18 (2) | 130 (41) | < .0001 |
| −18 or 18q− | 3 (0.4) | 61 (19) | < .0001 |
| −20 or 20q− | 32 (4) | 61 (19) | < .0001 |
| +21 or +21q | 49 (7) | 23 (7) | .79 |
| +22 or +22q | 18 (2) | 13 (4) | .17 |
| MDS-related cytogenetic changes† | 238 (32) | 265 (83) | < .0001 |
| Complex karyotype* | 93 (13) | 242 (76) | < .0001 |
| Molecular genetic abnormalities | |||
| NPM1 mutation | 59 (10) | 3 (1) | < .0001 |
| No. missing | 161 | 66 | |
| FLT3-ITD | 102 (16) | 10 (4) | < .0001 |
| No. missing | 118 | 47 | |
| FLT3-TKD | 36 (7) | 6 (2) | .02 |
| No. missing | 181 | 68 |
| Characteristics . | MK−, n (%) . | MK+, n (%) . | P . |
|---|---|---|---|
| Genetic group | |||
| Risk category* | |||
| Intermediate | 453 (61) | 5 (2) | < .0001 |
| Adverse | 286 (39) | 314 (98) | |
| Cytogenetic abnormalities | |||
| t(9;11) | 55 (7) | 0 (0) | < .0001 |
| t(v;11)(v;q23) | 54 (7) | 7 (2) | .0008 |
| t(6;9) | 16 (2) | 3 (1) | .21 |
| inv(3) or t(3;3) | 11 (2) | 34 (11) | < .0001 |
| −5 or 5q− | 61 (8) | 174 (55) | < .0001 |
| −7 | 42 (6) | 142 (45) | < .0001 |
| 7q− | 54 (7) | 54 (17) | < .0001 |
| +8 or +8q | 205 (28) | 45 (14) | < .0001 |
| +11 or +11q | 37 (5) | 20 (6) | .46 |
| abnl(12p) | 45 (6) | 77 (24) | < .0001 |
| +13 or +13q | 33 (5) | 10 (3) | .40 |
| abnl(17p) | 18 (2) | 130 (41) | < .0001 |
| −18 or 18q− | 3 (0.4) | 61 (19) | < .0001 |
| −20 or 20q− | 32 (4) | 61 (19) | < .0001 |
| +21 or +21q | 49 (7) | 23 (7) | .79 |
| +22 or +22q | 18 (2) | 13 (4) | .17 |
| MDS-related cytogenetic changes† | 238 (32) | 265 (83) | < .0001 |
| Complex karyotype* | 93 (13) | 242 (76) | < .0001 |
| Molecular genetic abnormalities | |||
| NPM1 mutation | 59 (10) | 3 (1) | < .0001 |
| No. missing | 161 | 66 | |
| FLT3-ITD | 102 (16) | 10 (4) | < .0001 |
| No. missing | 118 | 47 | |
| FLT3-TKD | 36 (7) | 6 (2) | .02 |
| No. missing | 181 | 68 |