Comparison of chromosomal lesions in CML and normal CD34+ cells exposed to radiation
| Radiation dose . | Probes . | Stable aberrations . | Unstable aberrations . | Total (stable + unstable) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Normal, % . | CML, % . | P . | Normal, % . | CML, % . | P . | Normal, %) . | CML, % . | P . | ||
| First division | ||||||||||
| 0.5 Gy | 1, 5, 11 | 1.4 | 2.5 | .23 | 2.6 | 5.6 | .03 | 4.0 | 8.1 | .01 |
| 3, 7, 21 | 1.8 | 0.9 | .32 | 1.6 | 2.5 | .36 | 3.4 | 3.5 | .98 | |
| Combined | .84 | .02 | .05 | |||||||
| 2 Gy | 1, 5, 11 | 10.5 | 11.7 | .6 | 9.2 | 18.9 | .0004 | 19.7 | 30.6 | .003 |
| 3, 7, 21 | 6.1 | 6.8 | .73 | 7.6 | 8.5 | .63 | 13.7 | 15.3 | .56 | |
| Combined | .54 | .002 | .006 | |||||||
| Third to fourth division | ||||||||||
| 0.5 Gy | 1, 5, 11 | 2.4 | 1.2 | .18 | 0 | 3.2 | .03 | 2.4 | 4.4 | .12 |
| 3, 7, 21 | 1.7 | 1.7 | 1 | 0 | 2.7 | .04 | 1.7 | 4.4 | .04 | |
| Combined | .33 | .003 | .01 | |||||||
| 2 Gy | 1, 5, 11 | 10.1 | 8.4 | .38 | 0 | 8.8 | .003 | 10.1 | 17.2 | .004 |
| 3, 7, 21 | 8.7 | 6.2 | .16 | 0 | 7.8 | .004 | 8.7 | 14.0 | .02 | |
| Combined | .11 | < .0001 | .0002 | |||||||
| Radiation dose . | Probes . | Stable aberrations . | Unstable aberrations . | Total (stable + unstable) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Normal, % . | CML, % . | P . | Normal, % . | CML, % . | P . | Normal, %) . | CML, % . | P . | ||
| First division | ||||||||||
| 0.5 Gy | 1, 5, 11 | 1.4 | 2.5 | .23 | 2.6 | 5.6 | .03 | 4.0 | 8.1 | .01 |
| 3, 7, 21 | 1.8 | 0.9 | .32 | 1.6 | 2.5 | .36 | 3.4 | 3.5 | .98 | |
| Combined | .84 | .02 | .05 | |||||||
| 2 Gy | 1, 5, 11 | 10.5 | 11.7 | .6 | 9.2 | 18.9 | .0004 | 19.7 | 30.6 | .003 |
| 3, 7, 21 | 6.1 | 6.8 | .73 | 7.6 | 8.5 | .63 | 13.7 | 15.3 | .56 | |
| Combined | .54 | .002 | .006 | |||||||
| Third to fourth division | ||||||||||
| 0.5 Gy | 1, 5, 11 | 2.4 | 1.2 | .18 | 0 | 3.2 | .03 | 2.4 | 4.4 | .12 |
| 3, 7, 21 | 1.7 | 1.7 | 1 | 0 | 2.7 | .04 | 1.7 | 4.4 | .04 | |
| Combined | .33 | .003 | .01 | |||||||
| 2 Gy | 1, 5, 11 | 10.1 | 8.4 | .38 | 0 | 8.8 | .003 | 10.1 | 17.2 | .004 |
| 3, 7, 21 | 8.7 | 6.2 | .16 | 0 | 7.8 | .004 | 8.7 | 14.0 | .02 | |
| Combined | .11 | < .0001 | .0002 | |||||||
P values are for comparisons of normal and CML CD34+ cells. Results are pooled from multiple samples.