Cohort characteristics
| . | Low miR-650* . | High miR-650* . | P . |
|---|---|---|---|
| Number | n = 40 | n = 40 | |
| Median survival, mo | 161.2 | Not reached | .025† |
| Median time to treatment, mo | 33.9 | 60.4 | .036† |
| Median age, y (range) | 67.5 (46-85) | 69 (40-85) | .557‡ |
| F/M sex ratio | 25/15 | 23/17 | .857§ |
| Disease stage at the time of sample analysis | |||
| Low/intermediated stage of the disease (Rai 0, I, II), n (%) | 23 (57.5) | 32 (80.0) | .384§ |
| Advanced stage of the disease (Rai III, IV), n (%) | 14 (34.0) | 6 (15.0) | .136§ |
| Not determined, n (%) | 3 (7.5) | 2 (5.0) | |
| Treatment prior to sample analysis | |||
| Previously treated, n (%) | 21 (52.5) | 16 (40.0) | .554§ |
| Previously untreated, n (%) | 16 (40.0) | 24 (60.0) | .336§ |
| Not determined, n (%) | 3 (7.5) | 0 (0.0) | |
| IgVH status‖ | |||
| Unmutated IgVH, n (%) | 28 (70.0) | 19 (47.5) | .358§ |
| Mutated IgVH, n (%) | 11 (27.5) | 20 (50.0) | .205§ |
| Biclonal sample, n (%) | 1 (2.5) | 1 (2.5) | 1.00§ |
| Hierarchical cytogenetics (I-FISH)‖ | |||
| Deletion 17p13, n (%) | 7 (17.5) | 4 (10.0) | .525§ |
| Deletion 11q23, n (%) | 8 (20.0) | 5 (12.5) | .554§ |
| Trisomy 12, n (%) | 1 (2.5) | 2 (5.0) | 1 .00§ |
| Deletion 13q14, n (%) | 13 (32.5) | 17 (42.5) | .67§ |
| Normal, n (%) | 10 (25.0) | 12 (30.0) | .811§ |
| Not determined, n (%) | 1 (2.5) | 0 (0.0) |
| . | Low miR-650* . | High miR-650* . | P . |
|---|---|---|---|
| Number | n = 40 | n = 40 | |
| Median survival, mo | 161.2 | Not reached | .025† |
| Median time to treatment, mo | 33.9 | 60.4 | .036† |
| Median age, y (range) | 67.5 (46-85) | 69 (40-85) | .557‡ |
| F/M sex ratio | 25/15 | 23/17 | .857§ |
| Disease stage at the time of sample analysis | |||
| Low/intermediated stage of the disease (Rai 0, I, II), n (%) | 23 (57.5) | 32 (80.0) | .384§ |
| Advanced stage of the disease (Rai III, IV), n (%) | 14 (34.0) | 6 (15.0) | .136§ |
| Not determined, n (%) | 3 (7.5) | 2 (5.0) | |
| Treatment prior to sample analysis | |||
| Previously treated, n (%) | 21 (52.5) | 16 (40.0) | .554§ |
| Previously untreated, n (%) | 16 (40.0) | 24 (60.0) | .336§ |
| Not determined, n (%) | 3 (7.5) | 0 (0.0) | |
| IgVH status‖ | |||
| Unmutated IgVH, n (%) | 28 (70.0) | 19 (47.5) | .358§ |
| Mutated IgVH, n (%) | 11 (27.5) | 20 (50.0) | .205§ |
| Biclonal sample, n (%) | 1 (2.5) | 1 (2.5) | 1.00§ |
| Hierarchical cytogenetics (I-FISH)‖ | |||
| Deletion 17p13, n (%) | 7 (17.5) | 4 (10.0) | .525§ |
| Deletion 11q23, n (%) | 8 (20.0) | 5 (12.5) | .554§ |
| Trisomy 12, n (%) | 1 (2.5) | 2 (5.0) | 1 .00§ |
| Deletion 13q14, n (%) | 13 (32.5) | 17 (42.5) | .67§ |
| Normal, n (%) | 10 (25.0) | 12 (30.0) | .811§ |
| Not determined, n (%) | 1 (2.5) | 0 (0.0) |