Major coinhibitory molecules and their corresponding binding partners involved in attenuating antitumor immunity
| Receptor . | Binding partners . | |||
|---|---|---|---|---|
| Name . | Expression pattern . | Name . | Expression on normal cells . | Expression on malignant cells . |
| CTLA-4 | Activated T, TREG | CD80/CD86 | T, B, DCs, macrophages | Down-regulated on AML, MM18,20 |
| PD-1 | Activated T and B, NKT, monocytes, myeloid cells | PD-L1 | Activated T, B, DCs, macrophages, monocytes, nonlymphoid tissues | AML, NHL, MM20,32 |
| PD-L2 | DCs, monocytes | AML, NHL, MM20,32 | ||
| BTLA | T, B, DCs, myeloid cells | HVEM | T, B, DCs, NK, myeloid cells and nonlymphoid tissues | AML, CLL, NHL, MM67,68,75 |
| LAG-3 | Activated T, TREG, B, pDCs, NK | MHC-II | Activated T, B, DCs, macrophages, monocytes, endothelium | Down-regulated in tumors1 |
| TIM-3 | Th1 CD4+ T, CD8+ T, DCs, NK, monocytes, epithelium | Galectin-9 | CD4 T cells, Treg, DCs, fibroblasts, granulocytes, endothelium | AML, lymphoma93,94 |
| CD200R | Activated T, B, NK, DCs, mast cells, myeloid cells, neutrophils | CD200 | Activated T, B, DCs, thymocytes, endothelium, nonlymphoid tissues | AML, CLL, MM84,85,108 |
| Receptor . | Binding partners . | |||
|---|---|---|---|---|
| Name . | Expression pattern . | Name . | Expression on normal cells . | Expression on malignant cells . |
| CTLA-4 | Activated T, TREG | CD80/CD86 | T, B, DCs, macrophages | Down-regulated on AML, MM18,20 |
| PD-1 | Activated T and B, NKT, monocytes, myeloid cells | PD-L1 | Activated T, B, DCs, macrophages, monocytes, nonlymphoid tissues | AML, NHL, MM20,32 |
| PD-L2 | DCs, monocytes | AML, NHL, MM20,32 | ||
| BTLA | T, B, DCs, myeloid cells | HVEM | T, B, DCs, NK, myeloid cells and nonlymphoid tissues | AML, CLL, NHL, MM67,68,75 |
| LAG-3 | Activated T, TREG, B, pDCs, NK | MHC-II | Activated T, B, DCs, macrophages, monocytes, endothelium | Down-regulated in tumors1 |
| TIM-3 | Th1 CD4+ T, CD8+ T, DCs, NK, monocytes, epithelium | Galectin-9 | CD4 T cells, Treg, DCs, fibroblasts, granulocytes, endothelium | AML, lymphoma93,94 |
| CD200R | Activated T, B, NK, DCs, mast cells, myeloid cells, neutrophils | CD200 | Activated T, B, DCs, thymocytes, endothelium, nonlymphoid tissues | AML, CLL, MM84,85,108 |
T indicates T cells; B, B cells; pDCs, plasmacytoid dendritic cells; NK(T), natural killer (T) cells; CLL, chronic lymphoid leukemia; and (B-)NHL, (B-cell) non-Hodgkin lymphoma.