Table 1 Summary results for rs210134 and... | American Society of Hematology

Table 1

Summary results for rs210134 and rs210142 SNPs associated with CLL risk

SNP	Position, bp	Risk allele	UK-GWAS			SF-GWAS			GEC-GWAS			Replication			Combined
SNP	Position, bp	Risk allele	RAF	OR (95% CI)	P_trend	RAF	OR (95% CI)	P_trend	RAF	OR (95% CI)	P_trend	RAF	OR (95% CI)	P_trend	OR (95% CI)	P_trend	P_het (I²)
rs210134	33 648 187	G	0.68	1.31 (1.13-1.51)	2.95 × 10⁻⁴	0.69	1.56 (1.21-2.02)	6.39 × 10⁻⁴	0.70*	1.37 (1.08-1.75)*	.0096*	0.68	1.35 (1.19-1.54)	4.87 × 10⁻⁶	1.37 (1.22-1.53)	1.03 × 10⁻¹²	.50 (0%)
rs210142	33 654 815	C	0.70*	1.35 (1.17-1.57)*	6.82 × 10⁻⁵*	0.70*	1.58 (1.22-2.05)*	5.44 × 10⁻⁴*	0.70*	1.38 (1.09-1.76)*	.0077*	0.69	1.47 (1.28-1.68)	2.41 × 10⁻⁸	1.40 (1.25-1.57)	9.47 × 10⁻¹⁶	.59 (0%)

SNP	Position, bp	Risk allele	UK-GWAS			SF-GWAS			GEC-GWAS			Replication			Combined
SNP	Position, bp	Risk allele	RAF	OR (95% CI)	P_trend	RAF	OR (95% CI)	P_trend	RAF	OR (95% CI)	P_trend	RAF	OR (95% CI)	P_trend	OR (95% CI)	P_trend	P_het (I²)
rs210134	33 648 187	G	0.68	1.31 (1.13-1.51)	2.95 × 10⁻⁴	0.69	1.56 (1.21-2.02)	6.39 × 10⁻⁴	0.70*	1.37 (1.08-1.75)*	.0096*	0.68	1.35 (1.19-1.54)	4.87 × 10⁻⁶	1.37 (1.22-1.53)	1.03 × 10⁻¹²	.50 (0%)
rs210142	33 654 815	C	0.70*	1.35 (1.17-1.57)*	6.82 × 10⁻⁵*	0.70*	1.58 (1.22-2.05)*	5.44 × 10⁻⁴*	0.70*	1.38 (1.09-1.76)*	.0077*	0.69	1.47 (1.28-1.68)	2.41 × 10⁻⁸	1.40 (1.25-1.57)	9.47 × 10⁻¹⁶	.59 (0%)

RAF indicates risk allele frequencies (based on control data).

Imputed genotype.