Table 1 Biological characteristics of... | American Society of Hematology

Table 1

Biological characteristics of T-ALL with TCRβ-oncogene translocation

T-ALL UPN	Age, y	Phenotype	Oncogenetic	TCRβ partner	Karyotype
Pediatric T-ALL (n = 16)
282	15	IMβ	Negative	HOXA	46,XY[23]
246	11	IMβ	Negative	HOXA	ND
8	7	Pre-αβ	Negative	HOXA	46,XX[50]
284*	10	TCRγδ⁺	Negative	HOXA	46,XY,t(10;13)(q?;q?)[3]/46,XY[2]
290†	2	IMβ	Negative	MYB	46,XY,t(6;7)(q?23;q?)[19]/46,XY[3]
247†	2	IMγ	Negative	MYB	46,XX,t(6;7)(q?22;q35),t(8;14)(q22;q11),del(11)(q22)[14]/46,XX[1]
280‡	14	IMβ	TLX1	TLX1	46,XX,t(9;9)(q10;q10)[12]
336‡	12	IMβ	TLX1	TLX1	47,XX,del(9)(p12),+del(9)(p12)[9]/46,XX[5]
316‡	11	Pre-αβ	TLX1	TLX1	46–48,XY,inv(1)(p2?p3?),−4,−9,−9,−11,del(11)(q2?),del(12)(p?),−18,+5−7mar [cp17]/46,XY[3]
17	3	Pre-αβ	STIL-TAL1	IL2RB	46,XY[25]
374	12	TCRαβ⁺	Negative	LMO2	46,XX[20]
75	10	TCRαβ⁺	Negative	LMO2	46 XY,del(6)(q15q23)[1]/46,XY[38]
270	13	Pre-αβ	Negative	TAL1	47,XY,t(1;7)(p22;q32),−6,+8,del(9)(q13q21),add(17)(p?13),r(?6)[8]/46,XY[14]
346‡	5	IMβ	TLX1	TCRβ	ND
328†	1	Pre-αβ	Negative	MYB	46,XY,t(6;7)(q23;q35)[16]/46,XY[6]
308	10	IM0	Negative	Unknown	47,XY,+19[6]/46,XY[5]
Adult T-ALL (n = 24)
174	21	IM0	Negative	HOXA	46,XY,del(6)(p12p22),inv(14)(q22q31),add(20)(q11)[7]/46,XY,idem,add(8)(q24)[10]/46,XY[5]
366	28	Pre-αβ	Negative	HOXA	46,XY[20]
368	64	TCRαβ⁺	Negative	HOXA	ND
183	24	TCRγδ⁺	Negative	HOXA	46,XY[20]
181	29	TCRγδ⁺	Negative	HOXA	47,XY,+11[7]/47,XY,+21[4]/46,XY[1]
536	44	TCRγδ⁺	Negative	HOXA	46,XY[20]
347	16	TCRγδ⁺	Negative	HOXA	46,XY[26]
232	45	TCRγδ⁺	PICALM-MLLT10	HOXA	ND
264	38	TCRγδ⁺	PICALM-MLLT10	HOXA	46,XX,del(7)(p?),add(5)(q?)[9]
43‡	36	IMγ	TLX1	TLX1	46,XY[20]
546‡	28	IMβ	TLX1	TLX1	46,XY,add(4)(p?12),del(6)(q12),t(7;10)(q34;q24)[7]/46,XY[9]
474‡	32	Pre-αβ	TLX1	TLX1	46,XY,t(7;10)(q34;q24)[30]
57‡	35	Pre-αβ	TLX1	TLX1	46,XX[20]
84‡	17	Pre-αβ	TLX1	TLX1	46,XY,t(7;10)(q35;q24)[9]/46,XY,?t(5;18)(p11;p11)[3]/46,XY[3]
547‡	20	Pre-αβ	TLX1	TLX1	46,XY,t(7;10)(q34;q24)[15]/46,idem,del(6)(q2?1q2?6)[2]/46,XY[3]
500‡	26	Pre-αβ	TLX1	TCRδ and TLX1	46,XY[20]
28‡	47	Pre-αβ	TLX1	TLX1	46,XX[50]
379‡	58	Pre-αβ	TLX1	TLX1	46,XX,t(7;10)(q35;q24)[13]
234‡	16	IMβ	Negative	LMO1	46,XY,dup(2)(q11q37),?del(6)(p22)[15]
380	38	Pre-αβ	STIL-TAL1	LMO1	46.XX,add(9)(p?)[18]/46,XX[5]
178	26	Pre-αβ	Negative	LMO2	46,XY,t(7;11)(q35;p13)[16]/46,XY[1]
439	25	Pre-αβ	Negative	LEF-1	46,XY,t(4;7)(q2?5;q35),t(14;20)(q11;p1?2)[19]
497	19	Pre-αβ	Negative	Unknown	46,XY,t(7;9)(q34;q31),add(9)(q34)[18]
233	22	IMβ	TLX3	Unknown	48,XY,del(6)(q13q22),r(7),+8,+12[16]

T-ALL UPN	Age, y	Phenotype	Oncogenetic	TCRβ partner	Karyotype
Pediatric T-ALL (n = 16)
282	15	IMβ	Negative	HOXA	46,XY[23]
246	11	IMβ	Negative	HOXA	ND
8	7	Pre-αβ	Negative	HOXA	46,XX[50]
284*	10	TCRγδ⁺	Negative	HOXA	46,XY,t(10;13)(q?;q?)[3]/46,XY[2]
290†	2	IMβ	Negative	MYB	46,XY,t(6;7)(q?23;q?)[19]/46,XY[3]
247†	2	IMγ	Negative	MYB	46,XX,t(6;7)(q?22;q35),t(8;14)(q22;q11),del(11)(q22)[14]/46,XX[1]
280‡	14	IMβ	TLX1	TLX1	46,XX,t(9;9)(q10;q10)[12]
336‡	12	IMβ	TLX1	TLX1	47,XX,del(9)(p12),+del(9)(p12)[9]/46,XX[5]
316‡	11	Pre-αβ	TLX1	TLX1	46–48,XY,inv(1)(p2?p3?),−4,−9,−9,−11,del(11)(q2?),del(12)(p?),−18,+5−7mar [cp17]/46,XY[3]
17	3	Pre-αβ	STIL-TAL1	IL2RB	46,XY[25]
374	12	TCRαβ⁺	Negative	LMO2	46,XX[20]
75	10	TCRαβ⁺	Negative	LMO2	46 XY,del(6)(q15q23)[1]/46,XY[38]
270	13	Pre-αβ	Negative	TAL1	47,XY,t(1;7)(p22;q32),−6,+8,del(9)(q13q21),add(17)(p?13),r(?6)[8]/46,XY[14]
346‡	5	IMβ	TLX1	TCRβ	ND
328†	1	Pre-αβ	Negative	MYB	46,XY,t(6;7)(q23;q35)[16]/46,XY[6]
308	10	IM0	Negative	Unknown	47,XY,+19[6]/46,XY[5]
Adult T-ALL (n = 24)
174	21	IM0	Negative	HOXA	46,XY,del(6)(p12p22),inv(14)(q22q31),add(20)(q11)[7]/46,XY,idem,add(8)(q24)[10]/46,XY[5]
366	28	Pre-αβ	Negative	HOXA	46,XY[20]
368	64	TCRαβ⁺	Negative	HOXA	ND
183	24	TCRγδ⁺	Negative	HOXA	46,XY[20]
181	29	TCRγδ⁺	Negative	HOXA	47,XY,+11[7]/47,XY,+21[4]/46,XY[1]
536	44	TCRγδ⁺	Negative	HOXA	46,XY[20]
347	16	TCRγδ⁺	Negative	HOXA	46,XY[26]
232	45	TCRγδ⁺	PICALM-MLLT10	HOXA	ND
264	38	TCRγδ⁺	PICALM-MLLT10	HOXA	46,XX,del(7)(p?),add(5)(q?)[9]
43‡	36	IMγ	TLX1	TLX1	46,XY[20]
546‡	28	IMβ	TLX1	TLX1	46,XY,add(4)(p?12),del(6)(q12),t(7;10)(q34;q24)[7]/46,XY[9]
474‡	32	Pre-αβ	TLX1	TLX1	46,XY,t(7;10)(q34;q24)[30]
57‡	35	Pre-αβ	TLX1	TLX1	46,XX[20]
84‡	17	Pre-αβ	TLX1	TLX1	46,XY,t(7;10)(q35;q24)[9]/46,XY,?t(5;18)(p11;p11)[3]/46,XY[3]
547‡	20	Pre-αβ	TLX1	TLX1	46,XY,t(7;10)(q34;q24)[15]/46,idem,del(6)(q2?1q2?6)[2]/46,XY[3]
500‡	26	Pre-αβ	TLX1	TCRδ and TLX1	46,XY[20]
28‡	47	Pre-αβ	TLX1	TLX1	46,XX[50]
379‡	58	Pre-αβ	TLX1	TLX1	46,XX,t(7;10)(q35;q24)[13]
234‡	16	IMβ	Negative	LMO1	46,XY,dup(2)(q11q37),?del(6)(p22)[15]
380	38	Pre-αβ	STIL-TAL1	LMO1	46.XX,add(9)(p?)[18]/46,XX[5]
178	26	Pre-αβ	Negative	LMO2	46,XY,t(7;11)(q35;p13)[16]/46,XY[1]
439	25	Pre-αβ	Negative	LEF-1	46,XY,t(4;7)(q2?5;q35),t(14;20)(q11;p1?2)[19]
497	19	Pre-αβ	Negative	Unknown	46,XY,t(7;9)(q34;q31),add(9)(q34)[18]
233	22	IMβ	TLX3	Unknown	48,XY,del(6)(q13q22),r(7),+8,+12[16]

Applying a TCR-based classification¹: immature (IM) cases (surface and cytoplasmic TCRβ⁻) comprised IM0, IMδ, and IMγ subtypes (harboring, respectively, a germline configuration of all three TCRβ, TCRδ, and TCRγ loci, only a TCRδ rearrangement, or in addition TCRγ-rearranged locus, accompanied or not by an incompletely rearranged DJβ locus); IMβ/pre-αβ cases included IMβ and pre-αβ subtypes (displaying VβDJβ rearrangement and, respectively, either a cTCRβ⁻ or sTCR⁻/cTCRβ+ phenotype); TCRαβ and TCRγδ cases harbored a cell surface TCRαβ or TCRγδ . PICALM-MLLT10 and STIL-TAL1 fusion transcripts were detected using RT-PCR as described previously.¹TLX1 and TLX3 were detected using RQ-PCR as described previously.¹⁶

Negative indicates cases with neither PICALM-MLLT10 and STIL-TAL1 fusion transcripts nor TLX1/TLX3 overexpression; ND, not done; and unknown, LM-PCR failures.

Also reported in Soulier et al.⁴⁰

†

Also reported in Clappier et al.⁴¹

‡

Also reported in Dadi et al.¹⁵

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