Table 2 Biological characteristics of... | American Society of Hematology

Table 2

Biological characteristics of T-ALL with TCRδ-oncogene translocation

T-ALL UPN	Age, y	Phenotype	Oncogenetic	TCRδ partner	Karyotype
Pediatric T-ALL (n = 9)
103*	12	IMβ	TLX1	TLX1	46,XY[20]
346*	5	IMβ	TLX1	TLX1	ND
377	15	Pre-αβ	Negative	LMO2	47,XY,del(9)(p?),t(11;14)(p13.q11),+17[22]
169	13	Pre-αβ	Negative	LMO2	46,XY[20]
299	12	Pre-αβ	Negative	LMO2	46,XX[24]
86	14	Pre-αβ	Negative	TAL1	46,XY,inv(2)(p25q21)[22]
327	15	TCRαβ⁺	Negative	TAL1	ND
268	13	TCRαβ⁺	Negative	MYC	46,XY,t(8;14)(q24;q11)[18]/46,XY,i(17)(p10)[5]/46,XY[5]
391	7	IMβ	TLX3	IGLV5–45	47,XX,+8,del(9)(p21p24)[24]
Adult T-ALL (n = 29)
135*	24	IMβ	TLX1	TLX1	48,XY,del(3)(q27),add(4)(q34),+5,+21[9]/48,idem,−17,+mar[2]/46,XY[19]
516*	38	IMβ	TLX1	TLX1	46,XX[30]
506*	35	Pre-αβ	TLX1	TLX1	47,XY,del(6)(q16q24),del(8)(p11),t(10;14)(q24;q11),+mar[6]/46,XY[10]
480*	41	Pre-αβ	TLX1	TLX1	46,XY,del(6)(q13q23),add(9)(p11),t(10;14)(q24,q11)[8]/46,XY[4]
199*	31	Pre-αβ	TLX1	TLX1	ND
281*	18	Pre-αβ	TLX1	TLX1	46,XY[20]
496*	27	Pre-αβ	TLX1	TLX1	46,XY[20]
12*	34	Pre-αβ	TLX1	TLX1	ND
242*	42	Pre-αβ	TLX1	TLX1	46,XY,del(6)(q21q25),t(10;14)(q24;q11)[4]/46,XY[16]
362*	45	Pre-αβ	TLX1	TLX1	46,XY,t(10;14)(q24;q11)[14]/46,XY[4]
9*	48	Pre-αβ	TLX1	TLX1	ND
494*	53	Pre-αβ	TLX1	TLX1	50,idem,+8,t(10;14)(q24;q11),+18,+19,+20[19]
73*	20	Pre-αβ	TLX1	TLX1	46,XY,del(7)(q?),−9,−10,del(12)(p11),−14,−14,+4mar[12]/46,XY[8]
381*	43	Pre-αβ	TLX1	TLX1	46,XY[20]
164*	35	Pre-αβ	TLX1	TLX1	46,XY,t(9;20)(p21;q12),t(10;14)(q24;q11),del(12)(p12)[13]/46,XY[12]
528*	53	TCRγδ⁺	TLX1	TLX1	ND
499*	21	ND	TLX1	TLX1	46,XY[20]
500	26	Pre-αβ	TLX1	TLX1 and TCRβ	46,XY[20]
244	22	Pre-αβ	TLX1	GNAQ-TLX1	46,XX,t(5;17)(q31;p13),t(9;10;14)(p?;q22;?q23;q11)[20]
260	56	TCRαβ⁺	Negative	LMO2	ND
437	17	IMγ	Negative	LMO2	46,XY,t(11;14)(p13;q11)[6]/46,XY[12]
481	23	Pre-αβ	Negative	LMO2	46,XY[25]
23	16	Pre-αβ	STIL-TAL1	LMO2	45,XY,−7,del(9)(p21),t(11;14)(p13;q11);[19]
439	25	Pre-αβ	Negative	NKX2–4	46,XY,t(4;7)(q2?5;q35),t(14;20)(q11;p1?2)[19]
145	20	Pre-αβ	Negative	TAL1	ND
486	24	Pre-αβ	Negative	TAL1	46,XY,t(1;14)(p32;q11),del(9)(p?)[18]
92	33	TCRαβ⁺	Negative	TAL1	45,XY,der(1)t(1;9;14)(p32;p?;q?),der(9)t(1;9;14),−14[3]/47,XY,idem,+2mar[17]/46,XY[4]
45	22	IMβ	STIL-TAL1	Unknown	46,XY,t(5;20)(q32;p13)[3]/46,XY[17]
388	53	Pre-αβ	Negative	Unknown	45,XY,−8,der(8)t(8;?)(q24;?),t(9;14)(p21;q13)[18]

T-ALL UPN	Age, y	Phenotype	Oncogenetic	TCRδ partner	Karyotype
Pediatric T-ALL (n = 9)
103*	12	IMβ	TLX1	TLX1	46,XY[20]
346*	5	IMβ	TLX1	TLX1	ND
377	15	Pre-αβ	Negative	LMO2	47,XY,del(9)(p?),t(11;14)(p13.q11),+17[22]
169	13	Pre-αβ	Negative	LMO2	46,XY[20]
299	12	Pre-αβ	Negative	LMO2	46,XX[24]
86	14	Pre-αβ	Negative	TAL1	46,XY,inv(2)(p25q21)[22]
327	15	TCRαβ⁺	Negative	TAL1	ND
268	13	TCRαβ⁺	Negative	MYC	46,XY,t(8;14)(q24;q11)[18]/46,XY,i(17)(p10)[5]/46,XY[5]
391	7	IMβ	TLX3	IGLV5–45	47,XX,+8,del(9)(p21p24)[24]
Adult T-ALL (n = 29)
135*	24	IMβ	TLX1	TLX1	48,XY,del(3)(q27),add(4)(q34),+5,+21[9]/48,idem,−17,+mar[2]/46,XY[19]
516*	38	IMβ	TLX1	TLX1	46,XX[30]
506*	35	Pre-αβ	TLX1	TLX1	47,XY,del(6)(q16q24),del(8)(p11),t(10;14)(q24;q11),+mar[6]/46,XY[10]
480*	41	Pre-αβ	TLX1	TLX1	46,XY,del(6)(q13q23),add(9)(p11),t(10;14)(q24,q11)[8]/46,XY[4]
199*	31	Pre-αβ	TLX1	TLX1	ND
281*	18	Pre-αβ	TLX1	TLX1	46,XY[20]
496*	27	Pre-αβ	TLX1	TLX1	46,XY[20]
12*	34	Pre-αβ	TLX1	TLX1	ND
242*	42	Pre-αβ	TLX1	TLX1	46,XY,del(6)(q21q25),t(10;14)(q24;q11)[4]/46,XY[16]
362*	45	Pre-αβ	TLX1	TLX1	46,XY,t(10;14)(q24;q11)[14]/46,XY[4]
9*	48	Pre-αβ	TLX1	TLX1	ND
494*	53	Pre-αβ	TLX1	TLX1	50,idem,+8,t(10;14)(q24;q11),+18,+19,+20[19]
73*	20	Pre-αβ	TLX1	TLX1	46,XY,del(7)(q?),−9,−10,del(12)(p11),−14,−14,+4mar[12]/46,XY[8]
381*	43	Pre-αβ	TLX1	TLX1	46,XY[20]
164*	35	Pre-αβ	TLX1	TLX1	46,XY,t(9;20)(p21;q12),t(10;14)(q24;q11),del(12)(p12)[13]/46,XY[12]
528*	53	TCRγδ⁺	TLX1	TLX1	ND
499*	21	ND	TLX1	TLX1	46,XY[20]
500	26	Pre-αβ	TLX1	TLX1 and TCRβ	46,XY[20]
244	22	Pre-αβ	TLX1	GNAQ-TLX1	46,XX,t(5;17)(q31;p13),t(9;10;14)(p?;q22;?q23;q11)[20]
260	56	TCRαβ⁺	Negative	LMO2	ND
437	17	IMγ	Negative	LMO2	46,XY,t(11;14)(p13;q11)[6]/46,XY[12]
481	23	Pre-αβ	Negative	LMO2	46,XY[25]
23	16	Pre-αβ	STIL-TAL1	LMO2	45,XY,−7,del(9)(p21),t(11;14)(p13;q11);[19]
439	25	Pre-αβ	Negative	NKX2–4	46,XY,t(4;7)(q2?5;q35),t(14;20)(q11;p1?2)[19]
145	20	Pre-αβ	Negative	TAL1	ND
486	24	Pre-αβ	Negative	TAL1	46,XY,t(1;14)(p32;q11),del(9)(p?)[18]
92	33	TCRαβ⁺	Negative	TAL1	45,XY,der(1)t(1;9;14)(p32;p?;q?),der(9)t(1;9;14),−14[3]/47,XY,idem,+2mar[17]/46,XY[4]
45	22	IMβ	STIL-TAL1	Unknown	46,XY,t(5;20)(q32;p13)[3]/46,XY[17]
388	53	Pre-αβ	Negative	Unknown	45,XY,−8,der(8)t(8;?)(q24;?),t(9;14)(p21;q13)[18]

ND indicates not done; and unknown, LM-PCR failures.

Also reported in Dadi et al.¹⁵

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