Patient demographics
| Demographic characteristic . | Older group (N = 27) . | Younger group (N = 38) . | P . | |
|---|---|---|---|---|
| Age (range), y | 61 (51-71) | 29 (17-49) | ||
| Age 51-59 y | 12 (44) | |||
| Age 60-71 y | 15 (56) | |||
| Alloimmunized | 10 (36) | 8 (21) | .17 | |
| PNH clone >1% | 13 (40) | 17 (44) | .8 | |
| PNH clone size (range), % granulocytes | 1.3 (0.13-70) | 1.6 (0.02-53) | ||
| Median time from diagnosis to transplant (range), mo | 12 (4 mo-10 y) | 7 (2 mo-14 y) | .91 | |
| Previous ATG and CSA | 16 (54) | 18 (47) | .6 | |
| CSA | 8 (29) | 5 (13) | .12 | |
| Eltrombopag ± CSA/ATG | 1 (4) | 2 (5) | 1.0 | |
| Donor | ||||
| 10/10 MUD | 18 (66) | 23 (60) | .49 | |
| 9/10 UD | 3 (12) | 7 (18) | ||
| MSD | 6 (22) | 8 (22) | 1.0 | |
| Graft source | ||||
| PB | 27 (100) | 31 (81) | .03 | |
| HSCT index (≥3 vs < 3) | ||||
| HSCT 0-1 | 11 (37) | 22 (60) | .2 | |
| HSCT-2 | 6 (25) | 8 (22) | ||
| HSCT- 3 | 3 (14) | 3 (5) | ||
| HSCT > 3 | 7 (24) | 5 (13) | ||
| Cytogenetic abnormality | 1 | 0 | ||
| Somatic mutation | 1/20 | 0/20 | ||
| Donor age (range), y | 36 (22-64) | 31 (16-50) | .8 | |
| Donor CMV positive | 10 (39) | 14 (36) | 1.0 | |
| Demographic characteristic . | Older group (N = 27) . | Younger group (N = 38) . | P . | |
|---|---|---|---|---|
| Age (range), y | 61 (51-71) | 29 (17-49) | ||
| Age 51-59 y | 12 (44) | |||
| Age 60-71 y | 15 (56) | |||
| Alloimmunized | 10 (36) | 8 (21) | .17 | |
| PNH clone >1% | 13 (40) | 17 (44) | .8 | |
| PNH clone size (range), % granulocytes | 1.3 (0.13-70) | 1.6 (0.02-53) | ||
| Median time from diagnosis to transplant (range), mo | 12 (4 mo-10 y) | 7 (2 mo-14 y) | .91 | |
| Previous ATG and CSA | 16 (54) | 18 (47) | .6 | |
| CSA | 8 (29) | 5 (13) | .12 | |
| Eltrombopag ± CSA/ATG | 1 (4) | 2 (5) | 1.0 | |
| Donor | ||||
| 10/10 MUD | 18 (66) | 23 (60) | .49 | |
| 9/10 UD | 3 (12) | 7 (18) | ||
| MSD | 6 (22) | 8 (22) | 1.0 | |
| Graft source | ||||
| PB | 27 (100) | 31 (81) | .03 | |
| HSCT index (≥3 vs < 3) | ||||
| HSCT 0-1 | 11 (37) | 22 (60) | .2 | |
| HSCT-2 | 6 (25) | 8 (22) | ||
| HSCT- 3 | 3 (14) | 3 (5) | ||
| HSCT > 3 | 7 (24) | 5 (13) | ||
| Cytogenetic abnormality | 1 | 0 | ||
| Somatic mutation | 1/20 | 0/20 | ||
| Donor age (range), y | 36 (22-64) | 31 (16-50) | .8 | |
| Donor CMV positive | 10 (39) | 14 (36) | 1.0 | |
Values are n (%) unless otherwise noted.