Cox regression analysis of influence of baseline factors on OS
| . | n . | Univariate . | Multivariate . | ||||
|---|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | ||
| Year of diagnosis, per y | 6994 | 0.988 | 0.984-0.993 | <.001 | 0.991 | 0.987-0.996 | <.001 |
| Age, per y | 6993 | 1.052 | 1.050-1.054 | <.001 | 1.045 | 1.042-1.047 | <.001 |
| Sex | |||||||
| Female | 3370 | 1 | 1 | ||||
| Male | 3624 | 1.025 | 0.975-1.079 | .335 | 1.067 | 1.013-1.124 | .015 |
| AML type | |||||||
| De novo | 4833 | 1 | 1 | ||||
| tAML | 685 | 1.564 | 1.438-1.702 | <.001 | 1.535 | 1.409-1.673 | <.001 |
| MDS/AML | 902 | 1.741 | 1.616-1.876 | <.001 | 1.474 | 1.364-1.593 | <.001 |
| MPN/AML | 368 | 2.218 | 1.988-2.474 | <.001 | 1.935 | 1.730-2.165 | <.001 |
| ECOG/WHO PS | |||||||
| 0 | 1270 | 1 | 1 | ||||
| 1 | 2971 | 1.415 | 1.312-1.526 | <.001 | 1.254 | 1-162-1.353 | <.001 |
| 2 | 1238 | 2.405 | 2.204-2.624 | <.001 | 1.826 | 1.670-1.996 | <.001 |
| 3 | 837 | 4.355 | 3.957-4.793 | <.001 | 2.989 | 2.707-3.301 | <.001 |
| 4 | 437 | 6.590 | 5.869-7400 | <.001 | 5.176 | 4.598-5.827 | <.001 |
| . | n . | Univariate . | Multivariate . | ||||
|---|---|---|---|---|---|---|---|
| Hazard ratio . | 95% CI . | P . | Hazard ratio . | 95% CI . | P . | ||
| Year of diagnosis, per y | 6994 | 0.988 | 0.984-0.993 | <.001 | 0.991 | 0.987-0.996 | <.001 |
| Age, per y | 6993 | 1.052 | 1.050-1.054 | <.001 | 1.045 | 1.042-1.047 | <.001 |
| Sex | |||||||
| Female | 3370 | 1 | 1 | ||||
| Male | 3624 | 1.025 | 0.975-1.079 | .335 | 1.067 | 1.013-1.124 | .015 |
| AML type | |||||||
| De novo | 4833 | 1 | 1 | ||||
| tAML | 685 | 1.564 | 1.438-1.702 | <.001 | 1.535 | 1.409-1.673 | <.001 |
| MDS/AML | 902 | 1.741 | 1.616-1.876 | <.001 | 1.474 | 1.364-1.593 | <.001 |
| MPN/AML | 368 | 2.218 | 1.988-2.474 | <.001 | 1.935 | 1.730-2.165 | <.001 |
| ECOG/WHO PS | |||||||
| 0 | 1270 | 1 | 1 | ||||
| 1 | 2971 | 1.415 | 1.312-1.526 | <.001 | 1.254 | 1-162-1.353 | <.001 |
| 2 | 1238 | 2.405 | 2.204-2.624 | <.001 | 1.826 | 1.670-1.996 | <.001 |
| 3 | 837 | 4.355 | 3.957-4.793 | <.001 | 2.989 | 2.707-3.301 | <.001 |
| 4 | 437 | 6.590 | 5.869-7400 | <.001 | 5.176 | 4.598-5.827 | <.001 |
Multivariate analysis included parameters with a minimum of missing data (ie, those listed, but not cytogenetic data).
CI, confidence interval; MDS, myelodysplastic syndrome; MPN, myeloproliferative neoplasia; tAML, therapy-related AML.