Most common comutations in NPM1-mutated AML
| Gene mutation . | AML-NPM1 (n = 239), n (%) . | DN (n = 74), n (%) . | Myeloid (n = 72), n (%) . | Monocytic (n = 93), n (%) . | P* . | ||
|---|---|---|---|---|---|---|---|
| DN vs myeloid . | DN vs monocytic . | Myeloid vs monocytic . | |||||
| FLT-ITD | 98 (41) | 31 (42) | 39 (54) | 28 (30) | NS | NS | .008 |
| DNMT3A | 102 (43) | 20 (27) | 32 (44) | 50 (54) | .085 | .003 | NS |
| TET2/IDH | 144 (60) | 71 (96) | 28 (39) | 45 (48) | <.00001 | <.00001 | NS |
| TET2 | 56 (23) | 24 (32) | 9 (13) | 23 (25) | .016 | NS | NS |
| IDH1 | 44 (18) | 22 (30) | 10 (14) | 12 (13) | .067 | .03 | NS |
| IDH2 | 49 (21) | 27 (36) | 10 (14) | 12 (13) | .008 | .003 | NS |
| WT1 | 19 (8) | 1 (1) | 11 (15) | 7 (8) | .008 | NS | NS |
| SRSF2 | 25 (10) | 10 (14) | 3 (4) | 12 (13) | NS | NS | NS |
| RAS pathway | 72 (30) | 13 (18) | 22 (31) | 37 (40) | NS | .008 | NS |
| Gene mutation . | AML-NPM1 (n = 239), n (%) . | DN (n = 74), n (%) . | Myeloid (n = 72), n (%) . | Monocytic (n = 93), n (%) . | P* . | ||
|---|---|---|---|---|---|---|---|
| DN vs myeloid . | DN vs monocytic . | Myeloid vs monocytic . | |||||
| FLT-ITD | 98 (41) | 31 (42) | 39 (54) | 28 (30) | NS | NS | .008 |
| DNMT3A | 102 (43) | 20 (27) | 32 (44) | 50 (54) | .085 | .003 | NS |
| TET2/IDH | 144 (60) | 71 (96) | 28 (39) | 45 (48) | <.00001 | <.00001 | NS |
| TET2 | 56 (23) | 24 (32) | 9 (13) | 23 (25) | .016 | NS | NS |
| IDH1 | 44 (18) | 22 (30) | 10 (14) | 12 (13) | .067 | .03 | NS |
| IDH2 | 49 (21) | 27 (36) | 10 (14) | 12 (13) | .008 | .003 | NS |
| WT1 | 19 (8) | 1 (1) | 11 (15) | 7 (8) | .008 | NS | NS |
| SRSF2 | 25 (10) | 10 (14) | 3 (4) | 12 (13) | NS | NS | NS |
| RAS pathway | 72 (30) | 13 (18) | 22 (31) | 37 (40) | NS | .008 | NS |
P values represent values corrected for multiple comparisons.