Comparison of Hunger 1 and Hunger 2 regimens2
| Hunger 1 . | Hunger 2 . |
|---|---|
| Induction (4 weeks) | Induction (4 weeks) |
| Prednisone, IT methotrexate, vincristine, L-asparaginase | Prednisone, IT methotrexate, vincristine, L-asparaginase |
| Bone marrow biopsy at day 29 determines whether patient is in remission | Bone marrow biopsy at day 29 determines whether patient is in remission |
| Consolidation (4 weeks) | Consolidation (4 weeks) |
| IT methotrexate, 6-mercaptopurine, vincristine | IT methotrexate, 6-mercaptopurine, vincristine |
| Maintenance (continued for a total treatment duration of 2.5 years) | Interim maintenance (8 weeks) |
| IT methotrexate, oral methotrexate, 6-mercaptopurine, vincristine, dexamethasone | IT methotrexate, oral methotrexate, 6-mercaptopurine, vincristine, dexamethasone |
| Delayed intensification (8 weeks) | |
| IT methotrexate, vincristine, L-asparaginase, dexamethasone, doxorubicin, cyclophosphamide, cytarabine | |
| Maintenance (continued for a total treatment duration of 2.5 years) | |
| IT methotrexate, oral methotrexate, 6-mercaptopurine, vincristine, dexamethasone |
| Hunger 1 . | Hunger 2 . |
|---|---|
| Induction (4 weeks) | Induction (4 weeks) |
| Prednisone, IT methotrexate, vincristine, L-asparaginase | Prednisone, IT methotrexate, vincristine, L-asparaginase |
| Bone marrow biopsy at day 29 determines whether patient is in remission | Bone marrow biopsy at day 29 determines whether patient is in remission |
| Consolidation (4 weeks) | Consolidation (4 weeks) |
| IT methotrexate, 6-mercaptopurine, vincristine | IT methotrexate, 6-mercaptopurine, vincristine |
| Maintenance (continued for a total treatment duration of 2.5 years) | Interim maintenance (8 weeks) |
| IT methotrexate, oral methotrexate, 6-mercaptopurine, vincristine, dexamethasone | IT methotrexate, oral methotrexate, 6-mercaptopurine, vincristine, dexamethasone |
| Delayed intensification (8 weeks) | |
| IT methotrexate, vincristine, L-asparaginase, dexamethasone, doxorubicin, cyclophosphamide, cytarabine | |
| Maintenance (continued for a total treatment duration of 2.5 years) | |
| IT methotrexate, oral methotrexate, 6-mercaptopurine, vincristine, dexamethasone |
IT, intrathecal.