Table 3. TWAS findings meeting... | American Society of Hematology

Table 3.

TWAS findings meeting genome-wide significance

Tissue	Gene	Chr	Heritability of the gene	No. of SNPs*	Best GWAS P value†	TWAS Z-score	TWAS P value	PP‡
GTEx blood	SPSB1	1	0.25	3	1.99 × 10⁻⁷	5.20	2.03 × 10⁻⁷	0.997
GTEx liver	ERAP1	5	0.50	11	7.82 × 10⁻⁶	−4.90	9.47 × 10⁻⁷	0.349
YFS blood	SH2B3	12	0.046	22	2.87 × 10⁻⁶	5.15	2.67 × 10⁻⁷	0.158
GTEx blood	RP11-747H7.3	14	0.07	13	5.96 × 10⁻⁸	4.88	1.07 × 10⁻⁶	0.945
GTEx blood	RP4-737E23.2	20	0.19	2	2.10 × 10⁻⁷	−5.27	1.34 × 10⁻⁷	0.995

Tissue	Gene	Chr	Heritability of the gene	No. of SNPs*	Best GWAS P value†	TWAS Z-score	TWAS P value	PP‡
GTEx blood	SPSB1	1	0.25	3	1.99 × 10⁻⁷	5.20	2.03 × 10⁻⁷	0.997
GTEx liver	ERAP1	5	0.50	11	7.82 × 10⁻⁶	−4.90	9.47 × 10⁻⁷	0.349
YFS blood	SH2B3	12	0.046	22	2.87 × 10⁻⁶	5.15	2.67 × 10⁻⁷	0.158
GTEx blood	RP11-747H7.3	14	0.07	13	5.96 × 10⁻⁸	4.88	1.07 × 10⁻⁶	0.945
GTEx blood	RP4-737E23.2	20	0.19	2	2.10 × 10⁻⁷	−5.27	1.34 × 10⁻⁷	0.995

Level of significance: P = 3.13 × 10⁻⁶.

Chr, chromosome; SNP, single nucleotide polymorphism.

Number of SNPs included in the final gene prediction model.

The lowest SNP-specific P value in the region.

PP of colocalization between GWAS and eQTL signal.