Table 4.
Univariable and multivariable analyses (COX regression) identifying independent risk factors for PFS of patients with MDS with thrombocytopenia
| Variable | PFS | ||||
|---|---|---|---|---|---|
| Univariate Cox | Multivariate Cox | ||||
| HR (95% CI) | P | HR (95% CI) | P | ||
| Age (≧60 y vs <60 y)* | 2.420 (1.847-3.171) | .000 | 1.152 (0.801-1.655) | .446 | |
| Sex (male vs female) | 1.726 (1.302-2.288) | .000 | 1.388 (0.987-1.952) | .060 | |
| IPSS-R (higher risk vs lower risk) | 3.467 (2.518-4.773) | .000 | 3.045 (1.950-4.755) | .000 | |
| Group (A and B vs C) | 1.937 (1.257-2.985) | .003 | 1.126 (0.700-1.812) | .624 | |
| WT1 (≥4.9% vs <4.9%) | 2.147 (1.622-2.842) | .000 | 1.521 (1.077-2.146) | .017 | |
| PRAME (≥0.3% vs <0.3%) | 3.342 (1.993-5.604) | .000 | 1.801 (1.114-2.914) | .016 | |
| Treatment (HSCT vs Chemotherapy and HMA) | 0.710 (0.488-1.034) | .074 | 0.799 (0.514-1.241) | .318 | |
| Variable | PFS | ||||
|---|---|---|---|---|---|
| Univariate Cox | Multivariate Cox | ||||
| HR (95% CI) | P | HR (95% CI) | P | ||
| Age (≧60 y vs <60 y)* | 2.420 (1.847-3.171) | .000 | 1.152 (0.801-1.655) | .446 | |
| Sex (male vs female) | 1.726 (1.302-2.288) | .000 | 1.388 (0.987-1.952) | .060 | |
| IPSS-R (higher risk vs lower risk) | 3.467 (2.518-4.773) | .000 | 3.045 (1.950-4.755) | .000 | |
| Group (A and B vs C) | 1.937 (1.257-2.985) | .003 | 1.126 (0.700-1.812) | .624 | |
| WT1 (≥4.9% vs <4.9%) | 2.147 (1.622-2.842) | .000 | 1.521 (1.077-2.146) | .017 | |
| PRAME (≥0.3% vs <0.3%) | 3.342 (1.993-5.604) | .000 | 1.801 (1.114-2.914) | .016 | |
| Treatment (HSCT vs Chemotherapy and HMA) | 0.710 (0.488-1.034) | .074 | 0.799 (0.514-1.241) | .318 | |
*
Age was included in the analysis as a categorical variable on the basis of a best-split algorithm showing a statistical difference in OS between patients younger than 60 years and those aged 60 years or older (supplemental Figure 5A-B,D-E).