Table 4.

Goldman criteria classification of 41 missed infectious diseases first detected on autopsy in 185 HCT recipients between 1 January 2000 and 31 December 2017

Goldman criteria classificationn (%)
Class I: missed major diagnoses for which detection before death would in all probability have led to a change in management that might have resulted in cure or prolonged survival 31 (75.6) 
 Fungal 14 (34.2) 
  Candida 4 (9.8) 
  Aspergillus 4 (9.8) 
  Mucorales 4 (9.8) 
  Scedosporium 1 (2.4) 
  Coccidioides 1 (2.4) 
 Viral 12 (29.3) 
  CMV 4 (9.8) 
  Adenovirus 4 (9.8) 
  HSV 2 (4.9) 
  VZV 1 (2.4) 
  RSV 1 (2.4) 
 Bacterial 3 (7.3) 
  Enterococcus 2 (4.9) 
  S aureus 1 (2.4) 
 Parasitic 2 (4.9) 
  S stercoralis 1 (2.4) 
  T gondii 1 (2.4) 
Class II: missed major diagnoses for which detection before death would probably not have led to a change in management 5 (12.2) 
 Viral 2 (4.9) 
  CMV 2 (4.9) 
 Bacterial 2 (4.9) 
  Gram-positive coccus 1 (2.4) 
  Gram-negative bacillus 1 (2.4) 
 Fungal 1 (2.4) 
  Aspergillus 1 (2.4) 
Class III: missed minor diagnoses related to the terminal disease process but not directly related to death 1 (2.4) 
 Fungal 1 (2.4) 
  Candida 1 (2.4) 
Class IV: either important unrelated diagnoses that might eventually have affected prognosis or processes that contributed to death in a terminally ill patient 4 (9.8) 
 Viral 4 (9.8) 
  BK virus 4 (9.8) 
Goldman criteria classificationn (%)
Class I: missed major diagnoses for which detection before death would in all probability have led to a change in management that might have resulted in cure or prolonged survival 31 (75.6) 
 Fungal 14 (34.2) 
  Candida 4 (9.8) 
  Aspergillus 4 (9.8) 
  Mucorales 4 (9.8) 
  Scedosporium 1 (2.4) 
  Coccidioides 1 (2.4) 
 Viral 12 (29.3) 
  CMV 4 (9.8) 
  Adenovirus 4 (9.8) 
  HSV 2 (4.9) 
  VZV 1 (2.4) 
  RSV 1 (2.4) 
 Bacterial 3 (7.3) 
  Enterococcus 2 (4.9) 
  S aureus 1 (2.4) 
 Parasitic 2 (4.9) 
  S stercoralis 1 (2.4) 
  T gondii 1 (2.4) 
Class II: missed major diagnoses for which detection before death would probably not have led to a change in management 5 (12.2) 
 Viral 2 (4.9) 
  CMV 2 (4.9) 
 Bacterial 2 (4.9) 
  Gram-positive coccus 1 (2.4) 
  Gram-negative bacillus 1 (2.4) 
 Fungal 1 (2.4) 
  Aspergillus 1 (2.4) 
Class III: missed minor diagnoses related to the terminal disease process but not directly related to death 1 (2.4) 
 Fungal 1 (2.4) 
  Candida 1 (2.4) 
Class IV: either important unrelated diagnoses that might eventually have affected prognosis or processes that contributed to death in a terminally ill patient 4 (9.8) 
 Viral 4 (9.8) 
  BK virus 4 (9.8) 
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