Table 1.

Treatment cohorts

Cohort no.BST-236 doseNo. of patients per protocol
1 Age <50 y: 0.5 g/m2 per d 1 patient 
Age ≥50 y: 0.3 g/m2 per d 2 patients 
2 Age <50 y: 1.5 g/m2 per d 0 patients 
Age ≥50 y: 0.8 g/m2 per d 3 patients (1 patient received 2 induction courses) 
3 Age <50 y: 3 g/m2 per d 0 patients 
Age ≥50 y: 1.5 g/m2 per d 4 patients (1 patient discontinued on day 2) 
4 Age <50 y: 4.5 g/m2 per d 1 patient 
Age ≥50 y: 2.3 g/m2 per d 5 patients 
5 4.5 g/m2 per d (no age limit) 3 patients 
6 6 g/m2 per d (no age limit) 7 patients (1 patient discontinued on day 2; 1 patient discontinued on day 3; 1 patient received 2 induction courses) 
Total  26 
Cohort no.BST-236 doseNo. of patients per protocol
1 Age <50 y: 0.5 g/m2 per d 1 patient 
Age ≥50 y: 0.3 g/m2 per d 2 patients 
2 Age <50 y: 1.5 g/m2 per d 0 patients 
Age ≥50 y: 0.8 g/m2 per d 3 patients (1 patient received 2 induction courses) 
3 Age <50 y: 3 g/m2 per d 0 patients 
Age ≥50 y: 1.5 g/m2 per d 4 patients (1 patient discontinued on day 2) 
4 Age <50 y: 4.5 g/m2 per d 1 patient 
Age ≥50 y: 2.3 g/m2 per d 5 patients 
5 4.5 g/m2 per d (no age limit) 3 patients 
6 6 g/m2 per d (no age limit) 7 patients (1 patient discontinued on day 2; 1 patient discontinued on day 3; 1 patient received 2 induction courses) 
Total  26 
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