Ten-year events according to risk group in CoALL 07-03
| Variable . | Risk group based on intention-to-treat . | |||||
|---|---|---|---|---|---|---|
| LR-R . | LR-S . | LR-I . | HR-R . | HR-S . | Total . | |
| Intention-to-treat, n | 103 | 241 | 36 | 19 | 374 | 773 |
| Nonresponder | — | — | — | — | 6 | 6 |
| Induction failure | — | — | — | — | 44 | 44 |
| Death in induction | — | 1 | — | — | 2 | 3 |
| CR achieved after induction | 103 | 240 | 36 | 19 | 322 | 720 |
| Death in CR, n | — | 1 | — | — | 9 | 10 |
| Relapses* | 9 | 28 | 6 | 2 | 55 | 100 |
| BM alone | 6 | 23 | 2 | 1 | 34 | 66 |
| BM + CNS | 1 | 3 | 2 | — | 8 | 14 |
| BM + other | 1 | — | — | — | 5 | 6 |
| CNS alone | 1 | 1 | 1 | 1 | 7 | 11 |
| Testis alone | — | — | 1 | — | 1 | 2 |
| Other alone | — | 1 | — | — | — | 1 |
| SMN, n | 2 | 1 | — | — | 8 | 11 |
| Cum. incidence SMN, % (SE %) | 1.0 (1.0) | 0.4 (0.4) | 0.0 (0.0) | 0.0 (0.0) | 2.2 (0.8) | 1.3 (0.4) |
| Survival, % (SE %) | ||||||
| 5-y pEFS | 91.1 (2.8) | 88.0 (2.1) | 83.3 (6.2) | 94.7 (5.1) | 79.6 (2.1) | 84.3 (1.3) |
| 5-y OS | 98.0 (1.4) | 96.7 (1.2) | 94.4 (3.8) | 100 (0.0) | 86.8 (1.8) | 92.1 (1.0) |
| 10-y pEFS | 88.9 (3.2) | 86.7 (2.3) | 83.3 (6.2) | 87.4 (8.4) | 78.7 (2.1) | 83.5 (1.4) |
| 10-y OS | 96.0 (1.9) | 95.8 (1.3) | 94.4 (3.8) | 91.7 (8.0) | 85.2 (1.9) | 90.7 (1.1) |
| 5-y CIR all relapses | 7.9 (2.7) | 10.8 (2.0) | 16.7 (6.3) | 5.3 (5.3) | 14.2 (1.8) | 12.2 (1.2) |
| 5-y CIR isolated CNS relapse | 1.0 (1.0) | 0.4 (0.4) | 2.8 (2.8) | 5.3 (5.3) | 1.9 (0.7) | 1.4 (0.4) |
| 5-y CIR any CNS relapse | 2.0 (1.4) | 1.7 (0.8) | 8.3 (4.7) | 5.3 (5.3) | 4.6 (1.1) | 3.5 (0.7) |
| Variable . | Risk group based on intention-to-treat . | |||||
|---|---|---|---|---|---|---|
| LR-R . | LR-S . | LR-I . | HR-R . | HR-S . | Total . | |
| Intention-to-treat, n | 103 | 241 | 36 | 19 | 374 | 773 |
| Nonresponder | — | — | — | — | 6 | 6 |
| Induction failure | — | — | — | — | 44 | 44 |
| Death in induction | — | 1 | — | — | 2 | 3 |
| CR achieved after induction | 103 | 240 | 36 | 19 | 322 | 720 |
| Death in CR, n | — | 1 | — | — | 9 | 10 |
| Relapses* | 9 | 28 | 6 | 2 | 55 | 100 |
| BM alone | 6 | 23 | 2 | 1 | 34 | 66 |
| BM + CNS | 1 | 3 | 2 | — | 8 | 14 |
| BM + other | 1 | — | — | — | 5 | 6 |
| CNS alone | 1 | 1 | 1 | 1 | 7 | 11 |
| Testis alone | — | — | 1 | — | 1 | 2 |
| Other alone | — | 1 | — | — | — | 1 |
| SMN, n | 2 | 1 | — | — | 8 | 11 |
| Cum. incidence SMN, % (SE %) | 1.0 (1.0) | 0.4 (0.4) | 0.0 (0.0) | 0.0 (0.0) | 2.2 (0.8) | 1.3 (0.4) |
| Survival, % (SE %) | ||||||
| 5-y pEFS | 91.1 (2.8) | 88.0 (2.1) | 83.3 (6.2) | 94.7 (5.1) | 79.6 (2.1) | 84.3 (1.3) |
| 5-y OS | 98.0 (1.4) | 96.7 (1.2) | 94.4 (3.8) | 100 (0.0) | 86.8 (1.8) | 92.1 (1.0) |
| 10-y pEFS | 88.9 (3.2) | 86.7 (2.3) | 83.3 (6.2) | 87.4 (8.4) | 78.7 (2.1) | 83.5 (1.4) |
| 10-y OS | 96.0 (1.9) | 95.8 (1.3) | 94.4 (3.8) | 91.7 (8.0) | 85.2 (1.9) | 90.7 (1.1) |
| 5-y CIR all relapses | 7.9 (2.7) | 10.8 (2.0) | 16.7 (6.3) | 5.3 (5.3) | 14.2 (1.8) | 12.2 (1.2) |
| 5-y CIR isolated CNS relapse | 1.0 (1.0) | 0.4 (0.4) | 2.8 (2.8) | 5.3 (5.3) | 1.9 (0.7) | 1.4 (0.4) |
| 5-y CIR any CNS relapse | 2.0 (1.4) | 1.7 (0.8) | 8.3 (4.7) | 5.3 (5.3) | 4.6 (1.1) | 3.5 (0.7) |
BM, bone marrow; CIR, cumulative incidence of relapse; Cum., cumulative.
All relapses within 10 years.