Prioritized clinical questions
| Perioperative VTE prophylaxis in major surgery in general |
| 1. Pharmacological prophylaxis vs mechanical prophylaxis |
| 2. Mechanical prophylaxis vs no prophylaxis |
| 3. Pneumatic compression devices vs graduated compression stockings |
| 4. Pharmacological prophylaxis combined with mechanical prophylaxis vs pharmacological prophylaxis alone |
| 5. Mechanical prophylaxis combined with pharmacological prophylaxis vs mechanical prophylaxis alone |
| 6. Insertion of an IVC filter vs no IVC filter |
| 7. Extended antithrombotic prophylaxis vs short-term antithrombotic prophylaxis |
| 8. Early vs delayed antithrombotic prophylaxis |
| Orthopedic surgery: total hip and knee arthroplasty |
| 9. ASA prophylaxis vs anticoagulants |
| 10. DOAC prophylaxis vs LMWH prophylaxis |
| 11. DOAC prophylaxis vs prophylaxis with another DOAC |
| 12. LMWH prophylaxis vs warfarin prophylaxis |
| 13. LMWH prophylaxis vs UFH prophylaxis |
| Orthopedic surgery: hip fracture repair |
| 14. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 15. LMWH prophylaxis vs UFH prophylaxis |
| Major general surgery |
| 16. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 17. LMWH prophylaxis vs UFH prophylaxis |
| Laparoscopic cholecystectomy |
| 18. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| Major neurosurgical procedures |
| 19. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 20. LMWH prophylaxis vs UFH prophylaxis |
| TURP |
| 21. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 22. LMWH prophylaxis vs UFH prophylaxis |
| Radical prostatectomy |
| 23. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 24. LMWH prophylaxis vs UFH prophylaxis |
| Cardiac or major vascular surgery |
| 25. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 26. LMWH prophylaxis vs UFH prophylaxis |
| Major trauma |
| 27. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 28. LMWH prophylaxis vs UFH prophylaxis |
| Major gynecological surgery |
| 29. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 30. LMWH prophylaxis vs UFH prophylaxis |
| Perioperative VTE prophylaxis in major surgery in general |
| 1. Pharmacological prophylaxis vs mechanical prophylaxis |
| 2. Mechanical prophylaxis vs no prophylaxis |
| 3. Pneumatic compression devices vs graduated compression stockings |
| 4. Pharmacological prophylaxis combined with mechanical prophylaxis vs pharmacological prophylaxis alone |
| 5. Mechanical prophylaxis combined with pharmacological prophylaxis vs mechanical prophylaxis alone |
| 6. Insertion of an IVC filter vs no IVC filter |
| 7. Extended antithrombotic prophylaxis vs short-term antithrombotic prophylaxis |
| 8. Early vs delayed antithrombotic prophylaxis |
| Orthopedic surgery: total hip and knee arthroplasty |
| 9. ASA prophylaxis vs anticoagulants |
| 10. DOAC prophylaxis vs LMWH prophylaxis |
| 11. DOAC prophylaxis vs prophylaxis with another DOAC |
| 12. LMWH prophylaxis vs warfarin prophylaxis |
| 13. LMWH prophylaxis vs UFH prophylaxis |
| Orthopedic surgery: hip fracture repair |
| 14. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 15. LMWH prophylaxis vs UFH prophylaxis |
| Major general surgery |
| 16. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 17. LMWH prophylaxis vs UFH prophylaxis |
| Laparoscopic cholecystectomy |
| 18. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| Major neurosurgical procedures |
| 19. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 20. LMWH prophylaxis vs UFH prophylaxis |
| TURP |
| 21. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 22. LMWH prophylaxis vs UFH prophylaxis |
| Radical prostatectomy |
| 23. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 24. LMWH prophylaxis vs UFH prophylaxis |
| Cardiac or major vascular surgery |
| 25. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 26. LMWH prophylaxis vs UFH prophylaxis |
| Major trauma |
| 27. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 28. LMWH prophylaxis vs UFH prophylaxis |
| Major gynecological surgery |
| 29. Pharmacological prophylaxis vs no pharmacological prophylaxis |
| 30. LMWH prophylaxis vs UFH prophylaxis |