The 12 Frankfurt Consensus Conference on PBM (2018)34 research recommendations
| Research recommendations . |
|---|
| Preoperative anemia |
| R1: Because published studies show major differences in the Hb values used for the definition of preoperative anemia, the expert panel recommends identifying optimal Hb thresholds in different patient groups as well as adequate cutoff values |
| R2: The expert panel suggests addressing the effects of iron supplementation in nonanemic but iron-deficient patients scheduled for major surgery |
| R3: The expert panel recommends investigating the use of short-acting erythropoietins plus iron supplementation in adult preoperative elective surgery patients with focus on long-term (un-)desirable effects, optimal dose, type of surgery (particularly cancer surgery), copresence of iron deficiency, and cost effectiveness |
| RBC concentrate transfusion threshold |
| R4: The expert panel recommends additional research on restrictive RBC transfusion thresholds for hemodynamically stable patients with acute upper or lower gastrointestinal bleeding; the panel does not recommend additional research in hemodynamically unstable patients with acute major bleeding |
| R5-R9: The expert panel suggests additional research on RBC transfusion support in patients with hematological and oncological diseases, coronary heart diseases, noncardiac/nonorthopedic surgery, or brain injury |
| Rx (no evidence): No additional research on Hb thresholds in acutely bleeding patients |
| Implementation of PBM programs |
| R10-R12: The expert panel suggests additional research on the impact of PBM programs on |
| a) adverse events and patient-important outcomes |
| b) compliance, adherence, and acceptability |
| c) cost-effectiveness |
| Reproducible definitions and outcome parameters have to be defined beforehand to evaluate the sustainability of PBM programs |
| Research recommendations . |
|---|
| Preoperative anemia |
| R1: Because published studies show major differences in the Hb values used for the definition of preoperative anemia, the expert panel recommends identifying optimal Hb thresholds in different patient groups as well as adequate cutoff values |
| R2: The expert panel suggests addressing the effects of iron supplementation in nonanemic but iron-deficient patients scheduled for major surgery |
| R3: The expert panel recommends investigating the use of short-acting erythropoietins plus iron supplementation in adult preoperative elective surgery patients with focus on long-term (un-)desirable effects, optimal dose, type of surgery (particularly cancer surgery), copresence of iron deficiency, and cost effectiveness |
| RBC concentrate transfusion threshold |
| R4: The expert panel recommends additional research on restrictive RBC transfusion thresholds for hemodynamically stable patients with acute upper or lower gastrointestinal bleeding; the panel does not recommend additional research in hemodynamically unstable patients with acute major bleeding |
| R5-R9: The expert panel suggests additional research on RBC transfusion support in patients with hematological and oncological diseases, coronary heart diseases, noncardiac/nonorthopedic surgery, or brain injury |
| Rx (no evidence): No additional research on Hb thresholds in acutely bleeding patients |
| Implementation of PBM programs |
| R10-R12: The expert panel suggests additional research on the impact of PBM programs on |
| a) adverse events and patient-important outcomes |
| b) compliance, adherence, and acceptability |
| c) cost-effectiveness |
| Reproducible definitions and outcome parameters have to be defined beforehand to evaluate the sustainability of PBM programs |