Typical laboratory test results for VWD subtypes
| . | Normal . | Type 1 . | Type 1C . | Type 2A . | Type 2B* . | Type 2M . | Type 2N . | Type 3 . |
|---|---|---|---|---|---|---|---|---|
| VWF:Ag | N | ↓↓ | ↓↓ | N, ↓, or ↓↓ | N, ↓, or ↓↓ | ↓ or ↓↓ | N or ↓ | Absent |
| VWF:RCo/VWF:Ag, VWF:GPIbM/VWF:Ag, VWFGPIbR/VWF:Ag | N | N | N | ↓↓ | ↓ or ↓↓ | ↓↓ | N | N/A |
| FVIII/VWF:Ag | N | N | N | N | N | N | ↓↓ | N/A |
| LD-RIPA | None | None | None | None | ↑↑ | None | None | None |
| Platelet count | N | N | N | N | N or ↓ | N | N | N |
| VWF multimers | N | N | N | ↓HMW | ↓HMW | N | N | Absent |
| VWFpp/VWF:Ag | N | N | ↑ or ↑↑ | N or↑ | N or ↑ | N | N | N/A |
| VWF:CB/VWF:Ag | N | N | N | ↓↓ | ↓ or ↓↓ | N or ↓ | N | N/A |
| . | Normal . | Type 1 . | Type 1C . | Type 2A . | Type 2B* . | Type 2M . | Type 2N . | Type 3 . |
|---|---|---|---|---|---|---|---|---|
| VWF:Ag | N | ↓↓ | ↓↓ | N, ↓, or ↓↓ | N, ↓, or ↓↓ | ↓ or ↓↓ | N or ↓ | Absent |
| VWF:RCo/VWF:Ag, VWF:GPIbM/VWF:Ag, VWFGPIbR/VWF:Ag | N | N | N | ↓↓ | ↓ or ↓↓ | ↓↓ | N | N/A |
| FVIII/VWF:Ag | N | N | N | N | N | N | ↓↓ | N/A |
| LD-RIPA | None | None | None | None | ↑↑ | None | None | None |
| Platelet count | N | N | N | N | N or ↓ | N | N | N |
| VWF multimers | N | N | N | ↓HMW | ↓HMW | N | N | Absent |
| VWFpp/VWF:Ag | N | N | ↑ or ↑↑ | N or↑ | N or ↑ | N | N | N/A |
| VWF:CB/VWF:Ag | N | N | N | ↓↓ | ↓ or ↓↓ | N or ↓ | N | N/A |
HMW, high molecular weight; LD-RIPA, low-dose ristocetin-induced platelet aggregation; N, normal; ↓, reduced; ↓↓, markedly reduced; ↑, increased; ↑↑, markedly increased.
Platelet-type VWD has a similar laboratory phenotype.