Recommendations on the perioperative therapeutic targets for patients with VWD undergoing surgery
| Source . | Major surgery . | Minor surgery . | ||
|---|---|---|---|---|
| Preoperative target plasma levels . | Postoperative target plasma levels . | Preoperative target plasma levels . | Postoperative target plasma levels . | |
| Nichols et al16 | VWF:RCo and FVIII:C > 100 | VWF:RCo and FVIII:C > 50 for ≥7-10 d; avoid VWF:RCo > 200 and FVIII:C > 250 | VWF:RCo and FVIII:C > 30; preferable >50 | VWF:RCo and FVIII:C > 30; preferable >50 for 3-5 d |
| Laffan et al24 | VWF:RCo and FVIII:C > 100 | FVIII:C > 50; duration not specified; “postoperative period” | VWF:RCo and FVIII:C > 50 | Not specified |
| Castaman et al28 | VWF:RCo and FVIII:C = 80-100 | VWF:RCo and FVIII:C = 80-100 for 36 h; then, >50 for 5-10 d; avoid FVIII:C > 150 | Trough FVIII:C > 30 | FVIII:C > 30 for 2-4 d |
| Windyga et al10 | VWF:RCo > 50; FVIII:C > 80-100 | Day of surgery: VWF:RCo > 50; FVIII:C > 80-100; days 1-7: VWF:RCo > 30; FVIII:C > 50; days 8-14: VWF:RCo and FVIII:C > 30; avoid FVIII:C > 250 | VWF:RCo > 50; FVIII:C > 80-100 | Trough VWF:RCo > 30 and FVIII:C > 50 for 3-5 d |
| Source . | Major surgery . | Minor surgery . | ||
|---|---|---|---|---|
| Preoperative target plasma levels . | Postoperative target plasma levels . | Preoperative target plasma levels . | Postoperative target plasma levels . | |
| Nichols et al16 | VWF:RCo and FVIII:C > 100 | VWF:RCo and FVIII:C > 50 for ≥7-10 d; avoid VWF:RCo > 200 and FVIII:C > 250 | VWF:RCo and FVIII:C > 30; preferable >50 | VWF:RCo and FVIII:C > 30; preferable >50 for 3-5 d |
| Laffan et al24 | VWF:RCo and FVIII:C > 100 | FVIII:C > 50; duration not specified; “postoperative period” | VWF:RCo and FVIII:C > 50 | Not specified |
| Castaman et al28 | VWF:RCo and FVIII:C = 80-100 | VWF:RCo and FVIII:C = 80-100 for 36 h; then, >50 for 5-10 d; avoid FVIII:C > 150 | Trough FVIII:C > 30 | FVIII:C > 30 for 2-4 d |
| Windyga et al10 | VWF:RCo > 50; FVIII:C > 80-100 | Day of surgery: VWF:RCo > 50; FVIII:C > 80-100; days 1-7: VWF:RCo > 30; FVIII:C > 50; days 8-14: VWF:RCo and FVIII:C > 30; avoid FVIII:C > 250 | VWF:RCo > 50; FVIII:C > 80-100 | Trough VWF:RCo > 30 and FVIII:C > 50 for 3-5 d |
All target plasma levels are expressed as international units per deciliter.