Table 1. Revised International Staging... | American Society of Hematology

Table 1.

Revised International Staging System

Prognostic factor	Criteria
ISS stage
I	Serum β₂-microglobulin <3.5 mg/L, serum albumin ≥3.5 g/dL
II	Not ISS stage I or III
III	Serum β₂-microglobulin ≥5.5 mg/L
CA by iFISH
High risk	Presence of del(17p) and/or translocation t(4;14) and/or translocation t(14;16)
Standard risk	No high-risk CA
LDH
Normal	Serum LDH below the upper limit of normal
High	Serum LDH above the upper limit of normal
A new model for risk stratification for MM
R-ISS stage
I	ISS stage I and standard-risk CA by iFISH and normal LDH
II	Not R-ISS stage I or III
III	ISS stage III and either high-risk CA by iFISH or high LDH

Prognostic factor	Criteria
ISS stage
I	Serum β₂-microglobulin <3.5 mg/L, serum albumin ≥3.5 g/dL
II	Not ISS stage I or III
III	Serum β₂-microglobulin ≥5.5 mg/L
CA by iFISH
High risk	Presence of del(17p) and/or translocation t(4;14) and/or translocation t(14;16)
Standard risk	No high-risk CA
LDH
Normal	Serum LDH below the upper limit of normal
High	Serum LDH above the upper limit of normal
A new model for risk stratification for MM
R-ISS stage
I	ISS stage I and standard-risk CA by iFISH and normal LDH
II	Not R-ISS stage I or III
III	ISS stage III and either high-risk CA by iFISH or high LDH

Reprinted from Palumbo et al² with permission.

CA, chromosomal abnormalities; iFISH, interphase fluorescence in situ hybridization; MM, multiple myeloma.