Multivariate survival associations of single HLA-A, -B, -C, -DRB1 mismatches in unrelated donor hematopoietic cell transplantation
Outcome . | BM* . | PBSC† . | ||
---|---|---|---|---|
7/8 (n = 985)‡ . | P value . | 7/8 (n = 803)‡ . | P value . | |
OS | 1.25 (1.13-1.38) | <.001 | 1.26 (1.11-1.43) | <.001 |
DFS | 1.23 (1.12-1.36) | <.001 | 1.17 (1.03-1.32) | .012 |
NRM | 1.40 (1.25-1.56) | <.001 | 1.38 (1.15-1.66) | <.001 |
Outcome . | BM* . | PBSC† . | ||
---|---|---|---|---|
7/8 (n = 985)‡ . | P value . | 7/8 (n = 803)‡ . | P value . | |
OS | 1.25 (1.13-1.38) | <.001 | 1.26 (1.11-1.43) | <.001 |
DFS | 1.23 (1.12-1.36) | <.001 | 1.17 (1.03-1.32) | .012 |
NRM | 1.40 (1.25-1.56) | <.001 | 1.38 (1.15-1.66) | <.001 |
Bold type indicates statistical significance.
BM, bone marrow; DFS, disease-free survival; NRM, nonrelapse mortality; OS, overall survival; PBSC, peripheral blood stem cells.
Data are from Lee et al.15 Baseline is the 8/8 transplants (n = 1840) against the 7/8 transplants. Ninety-two percent of hematopoietic cell transplantations were performed with BM. Models were adjusted for disease, disease stage, Karnofsky performance status, donor–patient cytomegalovirus serology, patient race and age, use of T-cell depletion, use of total body irradiation, graft source, donor age, patient–donor sex match, and year of transplantation.
Data are from Fürst et al.16 Baseline is the 8/8 transplants (n = 1511) against the 7/8 transplants. Eighty-seven percent of hematopoietic cell transplantations were performed with PBSC. Models were adjusted for disease stage, donor–patient cytomegalovirus serology, patient age, use of T-cell depletion, conditioning regimen intensity, patient–donor sex match, year of transplantation, time to transplantation, and donor origin (national vs international).
Shown are the relative risk values followed by the 95% confidence intervals in parentheses.