Screening for chronic disease complications
| Screening . |
|---|
| Pulmonary hypertension and prolonged QTc—echocardiogram, electrocardiogram |
| Proteinuria and high blood pressure—urinalysis, renal function tests, urine creatinine/protein, serum creatinine, assess glomerular filtration rate, consider renal ultrasound |
| Hepatopathy/gallbladder disease—liver size, aspartate aminotransferase, alanine aminotransferase, bilirubin levels, abdominal ultrasound |
| Splenomegaly/hypersplenism—physical examination and splenic ultrasound if necessary, complete blood count |
| Retinopathy—dilated ophthalmologic examination |
| Strokes, aneurysms, moyamoya—brain magnetic resonance imaging/MRA |
| AVN—imaging with plain films, magnetic resonance imaging |
| Chronic lung disease/asthma—pulmonary function tests |
| Iron overload—serial serum ferritins, imaging for hepatic iron |
| Red cell alloimmunization—red cell antibody testing; blood bank communication for transient red cell antibodies at all institutions where patient has received blood in the past |
| Screening . |
|---|
| Pulmonary hypertension and prolonged QTc—echocardiogram, electrocardiogram |
| Proteinuria and high blood pressure—urinalysis, renal function tests, urine creatinine/protein, serum creatinine, assess glomerular filtration rate, consider renal ultrasound |
| Hepatopathy/gallbladder disease—liver size, aspartate aminotransferase, alanine aminotransferase, bilirubin levels, abdominal ultrasound |
| Splenomegaly/hypersplenism—physical examination and splenic ultrasound if necessary, complete blood count |
| Retinopathy—dilated ophthalmologic examination |
| Strokes, aneurysms, moyamoya—brain magnetic resonance imaging/MRA |
| AVN—imaging with plain films, magnetic resonance imaging |
| Chronic lung disease/asthma—pulmonary function tests |
| Iron overload—serial serum ferritins, imaging for hepatic iron |
| Red cell alloimmunization—red cell antibody testing; blood bank communication for transient red cell antibodies at all institutions where patient has received blood in the past |
AVN, avascular necrosis; MRA, magnetic resonance angiogram.