Table 1. Study findings evaluating IV... | American Society of Hematology

Table 1.

Study findings evaluating IV iron use for IDA in patients presenting to the ED: RBC transfusion outcome

Reference	Study design	N	Intervention*	Primary outcome: RBC transfusion
Khadadah et al²⁰	Quality improvement	211	Educational session	• Achieved 91% appropriateness of RBC transfusion, improved from historical average 53% (target >80%)
			IDA algorithm for ED
			Use of ferumoxytol
de las Nieves Lopez et al¹⁵	Pre–post study	Not stated	Performance standards for:	• Overall number of yearly RBC transfusions declined by 19% • Report significant difference for RBC use (P = .014)
			Diagnosis of IDA
			Management of IDA with first loading dose of IV iron for outpatients and for ED patients
Fraser et al¹⁴	Pre–post study	103	Automatic ferritin screening in all blood samples from GP or ED with possible IDA	• Overall reduction in number of transfused units in their medical assessment unit, from 841 to 552 (an absolute reduction of 65.6%)
			Referral pathway for ED and GP to enable scheduling for IV iron in ambulatory care ward
			RN training
			Pharmacy pathway for IV iron

Reference	Study design	N	Intervention*	Primary outcome: RBC transfusion
Khadadah et al²⁰	Quality improvement	211	Educational session	• Achieved 91% appropriateness of RBC transfusion, improved from historical average 53% (target >80%)
			IDA algorithm for ED
			Use of ferumoxytol
de las Nieves Lopez et al¹⁵	Pre–post study	Not stated	Performance standards for:	• Overall number of yearly RBC transfusions declined by 19% • Report significant difference for RBC use (P = .014)
			Diagnosis of IDA
			Management of IDA with first loading dose of IV iron for outpatients and for ED patients
Fraser et al¹⁴	Pre–post study	103	Automatic ferritin screening in all blood samples from GP or ED with possible IDA	• Overall reduction in number of transfused units in their medical assessment unit, from 841 to 552 (an absolute reduction of 65.6%)
			Referral pathway for ED and GP to enable scheduling for IV iron in ambulatory care ward
			RN training
			Pharmacy pathway for IV iron

GP, general practitioner; RN, registered nurse.

Studies listed in this section did not include control or comparator group.