Potential grading schema for pain and patient-reported quality-of-life outcomes after curative therapy
| End point . | Measures . | Grade of cure . |
|---|---|---|
| Pain | Pain events; ain events requiring hospitalization; oral pain medications (narcotics and NSAIDs) per month and per year; parenteral opiate use per month and per year | 1: Pain completely relieved |
| 2: 75%-99% improvement | ||
| 3: 55%-74% improvement | ||
| 4: ≤50% improvement | ||
| 5: No improvement | ||
| Patient-reported quality-of-life outcomes | Pain, affect functionality; PROMIS; ASCQ-ME; PedsQL; PHENX toolkit; HPQ; SCSES; COPM | Grade per measure to assess improvement before and after (%) |
| 1: 100% | ||
| 2: 75% improvement | ||
| 3: 50% improvement | ||
| 4: 25% improvement | ||
| 5: No improvement |
| End point . | Measures . | Grade of cure . |
|---|---|---|
| Pain | Pain events; ain events requiring hospitalization; oral pain medications (narcotics and NSAIDs) per month and per year; parenteral opiate use per month and per year | 1: Pain completely relieved |
| 2: 75%-99% improvement | ||
| 3: 55%-74% improvement | ||
| 4: ≤50% improvement | ||
| 5: No improvement | ||
| Patient-reported quality-of-life outcomes | Pain, affect functionality; PROMIS; ASCQ-ME; PedsQL; PHENX toolkit; HPQ; SCSES; COPM | Grade per measure to assess improvement before and after (%) |
| 1: 100% | ||
| 2: 75% improvement | ||
| 3: 50% improvement | ||
| 4: 25% improvement | ||
| 5: No improvement |
ASCQ-ME, Adult Sickle Cell Quality of Life Measurement Information System; CPOM, Composite Functional Outcome; HPQ, Health and Work Performance questionnaire; NSAID, nonsteroidal anti-inflammatory drugs; PedsQL, Pediatric Quality of Life Inventory; PHENX, phenotypes and exposures; PROMIS, Patient-Reported Outcomes Measurement Information System; SCSES, Sickle Cell Self-Efficacy Scale.