Blood cell indices for Townes SS BM–transplanted Cyb5R3wt and Cyb5R3fl chimeras before tamoxifen treatment (day −1) and at end of 3-week study
| . | Pretamoxifen . | End of study . | Statistical significance, P . | |||
|---|---|---|---|---|---|---|
| SS/R3wt, n = 19 . | SS/R3fl, n = 14 . | SS/R3WT, n = 19 . | SS/R3KD, n = 14 . | SS/R3WT vs SS/R3wt . | SS/R3KD vs SS/R3fl . | |
| Hct, % | 31.99 ± 0.49 | 32.95 ± 0.84 | 31.59 ± 0.59 | 33.61 ± 0.87 | .403 | .692 |
| Hgb, g/dL | 11.21 ± 0.18 | 11.56 ± 0.28 | 11.24 ± 0.16 | 11.59 ± 0.26 | .809 | .786 |
| MCV, fL | 47.67 ± 0.72 | 51.17 ± 0.93 | 49.62 ± 0.31 | 51.51 ± 0.77 | .007 | .092 |
| RDW, % | 35.09 ± 0.68 | 34.49 ± 0.61 | 35.69 ± 0.6 | 33.84 ± 0.81 | .091 | .089 |
| MCH, pg | 16.73 ± 0.27 | 17.32 ± 0.35 | 17.54 ± 0.1 | 17.85 ± 0.26 | .005 | .102 |
| RBC, 1012/L | 6.74 ± 0.15 | 6.51 ± 0.12 | 6.37 ± 0.12 | 6.49 ± 0.12 | .032 | .835 |
| WBC, ×109/L | 14.67 ± 0.8 | 14.08 ± 1.09 | 14.12 ± 0.71 | 13.4 ± 0.91 | .225 | .204 |
| PLT, ×109/L | 403 ± 13.3 | 353 ± 16.6 | 362 ± 13.5 | 335 ± 15.2 | .077 | .142 |
| MPV, fL | 6.6 ± 0.05 | 6.7 ± 0.08 | 6.8 ± 0.07 | 6.7 ± 0.07 | .025 | .095 |
| . | Pretamoxifen . | End of study . | Statistical significance, P . | |||
|---|---|---|---|---|---|---|
| SS/R3wt, n = 19 . | SS/R3fl, n = 14 . | SS/R3WT, n = 19 . | SS/R3KD, n = 14 . | SS/R3WT vs SS/R3wt . | SS/R3KD vs SS/R3fl . | |
| Hct, % | 31.99 ± 0.49 | 32.95 ± 0.84 | 31.59 ± 0.59 | 33.61 ± 0.87 | .403 | .692 |
| Hgb, g/dL | 11.21 ± 0.18 | 11.56 ± 0.28 | 11.24 ± 0.16 | 11.59 ± 0.26 | .809 | .786 |
| MCV, fL | 47.67 ± 0.72 | 51.17 ± 0.93 | 49.62 ± 0.31 | 51.51 ± 0.77 | .007 | .092 |
| RDW, % | 35.09 ± 0.68 | 34.49 ± 0.61 | 35.69 ± 0.6 | 33.84 ± 0.81 | .091 | .089 |
| MCH, pg | 16.73 ± 0.27 | 17.32 ± 0.35 | 17.54 ± 0.1 | 17.85 ± 0.26 | .005 | .102 |
| RBC, 1012/L | 6.74 ± 0.15 | 6.51 ± 0.12 | 6.37 ± 0.12 | 6.49 ± 0.12 | .032 | .835 |
| WBC, ×109/L | 14.67 ± 0.8 | 14.08 ± 1.09 | 14.12 ± 0.71 | 13.4 ± 0.91 | .225 | .204 |
| PLT, ×109/L | 403 ± 13.3 | 353 ± 16.6 | 362 ± 13.5 | 335 ± 15.2 | .077 | .142 |
| MPV, fL | 6.6 ± 0.05 | 6.7 ± 0.08 | 6.8 ± 0.07 | 6.7 ± 0.07 | .025 | .095 |
SS/R3wt and SS/R3fl are SS/R3WT and SS/R3KD groups, respectively, before tamoxifen treatment. Values are mean plus or minus SEM using the paired Student t test.
Hct, hematocrit; Hgb, total hemoglobin; MCH, mean corpuscular Hb; MCV, mean corpuscular volume; MPV, mean platelet volume; PLT, platelet; RBC, red blood cell; RDW, red blood cell distribution width; WBC, leukocyte.