Table 3.

Blood cell indices for Townes SS BM-transplanted Cyb5R3wt and Cyb5R3fl chimeras before tamoxifen treatment (day −1) and at end of 12-week study

PretamoxifenEnd of studySignificance, P
SS/R3wt, n = 7SS/R3fl, n = 5SS/R3WT, n = 7SS/R3KD, n = 5SS/R3WT vs SS/R3wtSS/R3KD vs SS/R3fl
Hct, % 27.17 ± 2.22 24.08 ± 1.28 27.50 ± 1.65 22.98 ± 2.01 .853 .321 
Hgb, g/dL 9.51 ± 0.72 8.62 ± 0.39 9.76 ± 0.56 8.24 ± 0.75 .685 .425 
MCV, fL 48.4 ± 0.46 47.66 ± 0.67 45.59 ± 0.69 45.66 ± 0.75 .005 .075 
RDW, % 35.17 ± 1.33 37.12 ± 1.05 37.8 ± 0.84 37.8 ± 2.43 .014 .822 
MCH, pg 17.03 ± 0.26 17.1 ± 0.42 16.19 ± 0.24 16.4 ± 0.21 .035 .235 
RBC, 1012/L 5.62 ± 0.46 5.07 ± 0.33 6.03 ± 0.34 5.05 ± 0.47 .221 .934 
WBC, ×109/L 17.59 ± 2.46 12.64 ± 1.61 22.61 ± 2.46 11.46 ± 4.73 .028 .738 
PLT, ×109/L 360 ± 49.6 301 ± 35.7 481 ± 44.7 448 ± 95.5 .008 .188 
MPV, fL 6.76 ± 0.06 7.1 ± 1.64 6.7 ± 1.04 6.9 ± 0.12 .76 .286 
PretamoxifenEnd of studySignificance, P
SS/R3wt, n = 7SS/R3fl, n = 5SS/R3WT, n = 7SS/R3KD, n = 5SS/R3WT vs SS/R3wtSS/R3KD vs SS/R3fl
Hct, % 27.17 ± 2.22 24.08 ± 1.28 27.50 ± 1.65 22.98 ± 2.01 .853 .321 
Hgb, g/dL 9.51 ± 0.72 8.62 ± 0.39 9.76 ± 0.56 8.24 ± 0.75 .685 .425 
MCV, fL 48.4 ± 0.46 47.66 ± 0.67 45.59 ± 0.69 45.66 ± 0.75 .005 .075 
RDW, % 35.17 ± 1.33 37.12 ± 1.05 37.8 ± 0.84 37.8 ± 2.43 .014 .822 
MCH, pg 17.03 ± 0.26 17.1 ± 0.42 16.19 ± 0.24 16.4 ± 0.21 .035 .235 
RBC, 1012/L 5.62 ± 0.46 5.07 ± 0.33 6.03 ± 0.34 5.05 ± 0.47 .221 .934 
WBC, ×109/L 17.59 ± 2.46 12.64 ± 1.61 22.61 ± 2.46 11.46 ± 4.73 .028 .738 
PLT, ×109/L 360 ± 49.6 301 ± 35.7 481 ± 44.7 448 ± 95.5 .008 .188 
MPV, fL 6.76 ± 0.06 7.1 ± 1.64 6.7 ± 1.04 6.9 ± 0.12 .76 .286 

SS/R3wt and SS/R3fl are SS/R3WT and SS/R3KD groups, respectively, before tamoxifen treatment. Values are mean ± SEM using the paired Student t test.

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