Baseline evaluations specific to HCT for SCD
| Organ system . | Test/evaluation performed . |
|---|---|
| Pulmonary | Pulmonary function testing |
| Cardiac | Echocardiogram, including TRJ velocity |
| Hematologic | HLA antibody screen (mismatched donors) |
| Extended RBC phenotyping | |
| Quantification of RBC transfusions | |
| Ferritin (consider) | |
| HbS%, with simple or exchange transfusion to <30% prior to conditioning | |
| Neurologic | Brain MRI/MRA |
| Transcranial Doppler (consider) | |
| Neuropsychiatric evaluation (consider) | |
| Hepatic | FerriScan/liver MRI (based on transfusion burden ± ferritin) |
| Liver biopsy (based on liver iron concentration) | |
| Renal | Urinalysis |
| Urine albumin-to-creatinine ratio | |
| GFR | |
| Spleen | 99mTc sulfur colloid liver-spleen scan (consider) |
| Consultations | Social work |
| Psychology | |
| Child life (pediatric patients) | |
| Transfusion medicine | |
| Endocrinology (if iron overload or for discussion of fertility risks) | |
| OB/gynecology (if considering fertility preservation) | |
| Hepatology (for liver biopsy) | |
| Neurosurgery (if Moyamoya disease, for surgical revascularization) | |
| Pain/anesthesia (if chronic pain) | |
| Psychiatry (if preexisting psychiatric diagnoses) |
| Organ system . | Test/evaluation performed . |
|---|---|
| Pulmonary | Pulmonary function testing |
| Cardiac | Echocardiogram, including TRJ velocity |
| Hematologic | HLA antibody screen (mismatched donors) |
| Extended RBC phenotyping | |
| Quantification of RBC transfusions | |
| Ferritin (consider) | |
| HbS%, with simple or exchange transfusion to <30% prior to conditioning | |
| Neurologic | Brain MRI/MRA |
| Transcranial Doppler (consider) | |
| Neuropsychiatric evaluation (consider) | |
| Hepatic | FerriScan/liver MRI (based on transfusion burden ± ferritin) |
| Liver biopsy (based on liver iron concentration) | |
| Renal | Urinalysis |
| Urine albumin-to-creatinine ratio | |
| GFR | |
| Spleen | 99mTc sulfur colloid liver-spleen scan (consider) |
| Consultations | Social work |
| Psychology | |
| Child life (pediatric patients) | |
| Transfusion medicine | |
| Endocrinology (if iron overload or for discussion of fertility risks) | |
| OB/gynecology (if considering fertility preservation) | |
| Hepatology (for liver biopsy) | |
| Neurosurgery (if Moyamoya disease, for surgical revascularization) | |
| Pain/anesthesia (if chronic pain) | |
| Psychiatry (if preexisting psychiatric diagnoses) |
OB, obsetrics; TRJ, tricuspid regurgitant jet.