Table 1. Dinucleotide analysis of FLT3... | American Society of Hematology

Table 1.

Dinucleotide analysis of FLT3-ITD N-regions

Dinucleotide	No. obs	No. exp	Obs/exp ratio	P	Significant at P = .05
RR*
GG	80	45.88	1.74	<.001	Yes
AA	29	16.65	1.74	.003	Yes
GA	29	27.64	1.05	.409	No
AG	21	27.64	0.76	.921	No
YY*
CC	82	44.26	1.85	<.001	Yes
TT	11	6.62	1.66	.063	No
CT	11	17.12	0.64	.954	No
TC	15	17.12	0.88	.722	No
RY†
GC	16	45.06	0.36	<.001	Yes
GT	13	17.43	0.75	.172	No
AT	14	10.50	1.33	.891	No
AC	20	27.15	0.74	.092	No
YR†
CG	22	45.06	0.49	<.001	Yes
CA	17	27.15	0.63	.023	Yes
TG	14	17.43	0.80	.217	No
TA	10	10.50	0.95	.519	No

Dinucleotide	No. obs	No. exp	Obs/exp ratio	P	Significant at P = .05
RR*
GG	80	45.88	1.74	<.001	Yes
AA	29	16.65	1.74	.003	Yes
GA	29	27.64	1.05	.409	No
AG	21	27.64	0.76	.921	No
YY*
CC	82	44.26	1.85	<.001	Yes
TT	11	6.62	1.66	.063	No
CT	11	17.12	0.64	.954	No
TC	15	17.12	0.88	.722	No
RY†
GC	16	45.06	0.36	<.001	Yes
GT	13	17.43	0.75	.172	No
AT	14	10.50	1.33	.891	No
AC	20	27.15	0.74	.092	No
YR†
CG	22	45.06	0.49	<.001	Yes
CA	17	27.15	0.63	.023	Yes
TG	14	17.43	0.80	.217	No
TA	10	10.50	0.95	.519	No

Calculated using frequencies of individual nucleotides: G = 0.337, A = 0.203, T = 0.128, and C = 0.331.

Exp, expected; Obs, observed.

For the RR and YY dinucleotides, the P value reflects the cumulative binomial probability of the observed value exceeding or equaling the expected value.

†

For RY and YR dinucleotides, the P value is for observed values less than or equal to the expected value.

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