AEs occurring in at least 5% of patients within the first month after CAR T-cell infusion
| AE . | Grades 1-2, n (%) . | Grade 3, n (%) . | Grade 4, n (%) . | Grade 5, n (%) . |
|---|---|---|---|---|
| Lymphocytopenia | 0 | 0 | 89 (100) | 0 |
| Neutrocytopenia | 0 | 2 (2) | 87 (98) | 0 |
| Leukopenia | 1 (1) | 6 (7) | 82 (92) | 0 |
| Anemia | 16 (18) | 64 (72) | 9 (10) | 0 |
| CRS | 66 (74) | 15 (17) | 3 (3) | 1 (1) |
| Fever | 52 (58) | 32 (36) | 0 | 0 |
| Thrombocytopenia | 27 (30) | 10 (11) | 46 (52) | 0 |
| Hypotension | 73 (82) | 8 (9) | 0 | 0 |
| APTT prolonged | 66 (74) | 5 (6) | 0 | 0 |
| Sinus tachycardia | 67 (75) | 0 | 0 | 0 |
| Hypoalbuminemia | 63 (71) | 1 (1) | 0 | 0 |
| Hypoxia | 50 (56) | 2 (2) | 0 | 0 |
| Hypokalemia | 29 (33) | 12 (13) | 3 (3) | 0 |
| ALT increase | 28 (31) | 3 (3) | 0 | 0 |
| Alkaline phosphatase increase | 27 (30) | 1 (1) | 0 | 0 |
| Diarrhea | 20 (22) | 5 (6) | 0 | 0 |
| AST increase | 18 (20) | 6 (7) | 0 | 0 |
| Lung infection | 0 | 16 (18) | 0 | 3 (3) |
| Hypocalcemia | 14 (16) | 3 (3) | 0 | 0 |
| CRES | 11 (12) | 0 | 1 (1) | 0 |
| Fibrinogen decreased | 7 (8) | 4 (4) | 1 (1) | 0 |
| Hyponatremia | 10 (11) | 1 (1) | 0 | 0 |
| Heart failure | 4 (4) | 1 (1) | 0 | 0 |
| AE . | Grades 1-2, n (%) . | Grade 3, n (%) . | Grade 4, n (%) . | Grade 5, n (%) . |
|---|---|---|---|---|
| Lymphocytopenia | 0 | 0 | 89 (100) | 0 |
| Neutrocytopenia | 0 | 2 (2) | 87 (98) | 0 |
| Leukopenia | 1 (1) | 6 (7) | 82 (92) | 0 |
| Anemia | 16 (18) | 64 (72) | 9 (10) | 0 |
| CRS | 66 (74) | 15 (17) | 3 (3) | 1 (1) |
| Fever | 52 (58) | 32 (36) | 0 | 0 |
| Thrombocytopenia | 27 (30) | 10 (11) | 46 (52) | 0 |
| Hypotension | 73 (82) | 8 (9) | 0 | 0 |
| APTT prolonged | 66 (74) | 5 (6) | 0 | 0 |
| Sinus tachycardia | 67 (75) | 0 | 0 | 0 |
| Hypoalbuminemia | 63 (71) | 1 (1) | 0 | 0 |
| Hypoxia | 50 (56) | 2 (2) | 0 | 0 |
| Hypokalemia | 29 (33) | 12 (13) | 3 (3) | 0 |
| ALT increase | 28 (31) | 3 (3) | 0 | 0 |
| Alkaline phosphatase increase | 27 (30) | 1 (1) | 0 | 0 |
| Diarrhea | 20 (22) | 5 (6) | 0 | 0 |
| AST increase | 18 (20) | 6 (7) | 0 | 0 |
| Lung infection | 0 | 16 (18) | 0 | 3 (3) |
| Hypocalcemia | 14 (16) | 3 (3) | 0 | 0 |
| CRES | 11 (12) | 0 | 1 (1) | 0 |
| Fibrinogen decreased | 7 (8) | 4 (4) | 1 (1) | 0 |
| Hyponatremia | 10 (11) | 1 (1) | 0 | 0 |
| Heart failure | 4 (4) | 1 (1) | 0 | 0 |
APTT, activated partial thromboplastin time; ALT, alanine aminotransferase; AST, aspartate aminotransferase.