Patient characteristics in cohort 2
| . | d-rsKIR . | dsKIR . | rsKIR . | nsKIR . | P . |
|---|---|---|---|---|---|
| n | 32 | 55 | 33 | 156 | |
| Age of host, median (range), y | 37 (2-57) | 31 (5-64) | 31 (2-55) | 31 (2-61) | |
| Donor and host sex group, n (%) | NS | ||||
| Male-male | 12 (37.5) | 22 (40) | 14 (42.4) | 68 (43.6) | |
| Male-female | 5 (15.6) | 18 (32.7) | 9 (27.3) | 43 (27.6) | |
| Female-male | 11 (34.4) | 8 (14.5) | 7 (21.2) | 24 (15.4) | |
| Female-female | 4 (12.5) | 7 (12.7) | 3 (9.1) | 21 (13.5) | |
| Donor and host relationship, n (%) | NS | ||||
| Child-parent | 11 (34.4) | 14 (25.5) | 7 (21.2) | 32 (20.5) | |
| Sibling | 9 (28.1) | 16 (29.1) | 12 (36.4) | 52 (33.3) | |
| Parent-child | 12 (37.5) | 25 (45.5) | 14 (42.4) | 68 (43.6) | |
| Collateral relative | 0 (0) | 0 (0) | 0 (0) | 4 (2.6) | |
| Disease category, n (%) | NS | ||||
| AML | 23 (71.9) | 40 (72.7) | 25 (75.8) | 115 (73.7) | |
| MDS | 9 (28.1) | 15 (27.3) | 8 (24.2) | 41 (26.3) | |
| Disease risk, n (%) | NS | ||||
| High | 12 (37.5) | 19 (34.5) | 10 (30.3) | 58 (37.2) | |
| Disease risk index, n (%) | NS | ||||
| Low | 2 (6.5) | 5 (9.1) | 2 (6.1) | 25 (16) | |
| Intermediate | 23 (74.2) | 43 (78.2) | 24 (72.7) | 97 (62.2) | |
| High or very high | 6 (19.4) | 7 (12.7) | 7 (21.2) | 34 (21.8) | |
| MRD status before transplantation, n (%) | NS | ||||
| Negative | 11 (36.7) | 27 (49.1) | 14 (42.4) | 46 (29.7) | |
| FCM and molecular positive | 8 (26.7) | 15 (27.3) | 7 (21.2) | 52 (33.5) | |
| Only FCM positive | 2 (6.7) | 2 (3.6) | 3 (9.1) | 10 (6.5) | |
| Only molecular positive | 9 (30) | 11 (20) | 9 (27.3) | 47 (30.3) | |
| Loci of HLA-A,B,DR mismatch, n (%) | .027 | ||||
| 0 | 1 (3.1) | 0 (0) | 1 (3.0) | 0 (0) | |
| 1 | 2 (6.3) | 1 (1.8) | 0 (0) | 7 (4.5) | |
| 2 | 10 (31.3) | 5 (9.1) | 5 (15.2) | 38 (24.4) | |
| 3 | 19 (59.4) | 49 (89.1) | 27 (81.8) | 111 (71.2) | |
| Missing self (donor ligand view), n (%) | 0 (0) | 0 (0) | 33 (100) | 156 (100) | <.01 |
| Missing self (host ligand view), n (%) | 0 (0) | 55 (100) | 0 (0) | 156 (100) | <.01 |
| Ligand-ligand GVH mismatch, n (%) | 0 (0) | 55 (100) | 0 (0) | 41 (26.3) | <.01 |
| Donor KIR haplotype, n (%) | NS | ||||
| AA | 22 (71) | 29 (54.7) | 18 (56.3) | 77 (50.3) | |
| BX | 9 (29) | 24 (45.3) | 14 (43.8) | 76 (49.7) | |
| KIR2DL1 single+group, n (%) | <.01 | ||||
| nsKIR (donor C1C1 to host C1C1) | 0 (0) | 0 (0) | 0 (0) | 110 (70.5) | |
| d-rsKIR (donor C2Cx to host C2Cx) | 32 (100) | 14 (25.5) | 17 (51.5) | 21 (13.5) | |
| dsKIR (donor C2CX to host C1C1) | 0 (0) | 41 (74.5) | 0 (0) | 18 (11.5) | |
| rsKIR (donor C1C1 to host C2Cx) | 0 (0) | 0 (0) | 16 (48.5) | 7 (4.5) | |
| KIR2DL2/L3 single+group, n (%) | <.01 | ||||
| nsKIR (donor C2C2 to host C2C2) | 0 (0) | 0 (0) | 0 (0) | 1 (0.6) | |
| d-rsKIR (donor C1Cx to host C1Cx) | 32 (100) | 46 (83.6) | 23 (69.7) | 143 (91.7) | |
| dsKIR (donor C1CX to host C2C2) | 0 (0) | 9 (16.4) | 0 (0) | 2 (1.3) | |
| rsKIR (donor C2C2 to host C1Cx) | 0 (0) | 0 (0) | 10 (30.3) | 10 (6.4) | |
| KIR3DL1 single+group, n (%) | <.01 | ||||
| nsKIR (donor Bw6Bw6 to host Bw6Bw6) | 0 (0) | 0 (0) | 0 (0) | 73 (46.8) | |
| d-rsKIR (donor Bw4Bwx to host Bw4Bwx) | 32 (100) | 34 (61.8) | 22 (66.7) | 38 (24.4) | |
| dsKIR (donor Bw4Bwx to host Bw6Bw6) | 0 (0) | 21 (38.2) | 0 (0) | 19 (12.2) | |
| rsKIR (donor Bw6Bw6 to host Bw4Bwx) | 0 (0) | 0 (0) | 11 (33.3) | 26 (16.7) | |
| Acute GVHD, n (%) | NS | ||||
| I | 9 (28.1) | 17 (30.9) | 9 (27.3) | 52 (33.3) | |
| II | 6 (18.8) | 7 (12.7) | 7 (21.2) | 24 (15.4) | |
| III | 2 (6.3) | 2 (3.6) | 3 (9.1) | 10 (6.4) | |
| IV | 2 (6.3) | 2 (3.6) | 3 (9.1) | 2 (1.3) | |
| Relapse | 0 (0) | 4 (7.3) | 4 (12.1) | 23 (14.7) | .025 |
| TRM | 4 (12.5) | 10 (18.2) | 7 (21.2) | 27 (17.3) | NS |
| . | d-rsKIR . | dsKIR . | rsKIR . | nsKIR . | P . |
|---|---|---|---|---|---|
| n | 32 | 55 | 33 | 156 | |
| Age of host, median (range), y | 37 (2-57) | 31 (5-64) | 31 (2-55) | 31 (2-61) | |
| Donor and host sex group, n (%) | NS | ||||
| Male-male | 12 (37.5) | 22 (40) | 14 (42.4) | 68 (43.6) | |
| Male-female | 5 (15.6) | 18 (32.7) | 9 (27.3) | 43 (27.6) | |
| Female-male | 11 (34.4) | 8 (14.5) | 7 (21.2) | 24 (15.4) | |
| Female-female | 4 (12.5) | 7 (12.7) | 3 (9.1) | 21 (13.5) | |
| Donor and host relationship, n (%) | NS | ||||
| Child-parent | 11 (34.4) | 14 (25.5) | 7 (21.2) | 32 (20.5) | |
| Sibling | 9 (28.1) | 16 (29.1) | 12 (36.4) | 52 (33.3) | |
| Parent-child | 12 (37.5) | 25 (45.5) | 14 (42.4) | 68 (43.6) | |
| Collateral relative | 0 (0) | 0 (0) | 0 (0) | 4 (2.6) | |
| Disease category, n (%) | NS | ||||
| AML | 23 (71.9) | 40 (72.7) | 25 (75.8) | 115 (73.7) | |
| MDS | 9 (28.1) | 15 (27.3) | 8 (24.2) | 41 (26.3) | |
| Disease risk, n (%) | NS | ||||
| High | 12 (37.5) | 19 (34.5) | 10 (30.3) | 58 (37.2) | |
| Disease risk index, n (%) | NS | ||||
| Low | 2 (6.5) | 5 (9.1) | 2 (6.1) | 25 (16) | |
| Intermediate | 23 (74.2) | 43 (78.2) | 24 (72.7) | 97 (62.2) | |
| High or very high | 6 (19.4) | 7 (12.7) | 7 (21.2) | 34 (21.8) | |
| MRD status before transplantation, n (%) | NS | ||||
| Negative | 11 (36.7) | 27 (49.1) | 14 (42.4) | 46 (29.7) | |
| FCM and molecular positive | 8 (26.7) | 15 (27.3) | 7 (21.2) | 52 (33.5) | |
| Only FCM positive | 2 (6.7) | 2 (3.6) | 3 (9.1) | 10 (6.5) | |
| Only molecular positive | 9 (30) | 11 (20) | 9 (27.3) | 47 (30.3) | |
| Loci of HLA-A,B,DR mismatch, n (%) | .027 | ||||
| 0 | 1 (3.1) | 0 (0) | 1 (3.0) | 0 (0) | |
| 1 | 2 (6.3) | 1 (1.8) | 0 (0) | 7 (4.5) | |
| 2 | 10 (31.3) | 5 (9.1) | 5 (15.2) | 38 (24.4) | |
| 3 | 19 (59.4) | 49 (89.1) | 27 (81.8) | 111 (71.2) | |
| Missing self (donor ligand view), n (%) | 0 (0) | 0 (0) | 33 (100) | 156 (100) | <.01 |
| Missing self (host ligand view), n (%) | 0 (0) | 55 (100) | 0 (0) | 156 (100) | <.01 |
| Ligand-ligand GVH mismatch, n (%) | 0 (0) | 55 (100) | 0 (0) | 41 (26.3) | <.01 |
| Donor KIR haplotype, n (%) | NS | ||||
| AA | 22 (71) | 29 (54.7) | 18 (56.3) | 77 (50.3) | |
| BX | 9 (29) | 24 (45.3) | 14 (43.8) | 76 (49.7) | |
| KIR2DL1 single+group, n (%) | <.01 | ||||
| nsKIR (donor C1C1 to host C1C1) | 0 (0) | 0 (0) | 0 (0) | 110 (70.5) | |
| d-rsKIR (donor C2Cx to host C2Cx) | 32 (100) | 14 (25.5) | 17 (51.5) | 21 (13.5) | |
| dsKIR (donor C2CX to host C1C1) | 0 (0) | 41 (74.5) | 0 (0) | 18 (11.5) | |
| rsKIR (donor C1C1 to host C2Cx) | 0 (0) | 0 (0) | 16 (48.5) | 7 (4.5) | |
| KIR2DL2/L3 single+group, n (%) | <.01 | ||||
| nsKIR (donor C2C2 to host C2C2) | 0 (0) | 0 (0) | 0 (0) | 1 (0.6) | |
| d-rsKIR (donor C1Cx to host C1Cx) | 32 (100) | 46 (83.6) | 23 (69.7) | 143 (91.7) | |
| dsKIR (donor C1CX to host C2C2) | 0 (0) | 9 (16.4) | 0 (0) | 2 (1.3) | |
| rsKIR (donor C2C2 to host C1Cx) | 0 (0) | 0 (0) | 10 (30.3) | 10 (6.4) | |
| KIR3DL1 single+group, n (%) | <.01 | ||||
| nsKIR (donor Bw6Bw6 to host Bw6Bw6) | 0 (0) | 0 (0) | 0 (0) | 73 (46.8) | |
| d-rsKIR (donor Bw4Bwx to host Bw4Bwx) | 32 (100) | 34 (61.8) | 22 (66.7) | 38 (24.4) | |
| dsKIR (donor Bw4Bwx to host Bw6Bw6) | 0 (0) | 21 (38.2) | 0 (0) | 19 (12.2) | |
| rsKIR (donor Bw6Bw6 to host Bw4Bwx) | 0 (0) | 0 (0) | 11 (33.3) | 26 (16.7) | |
| Acute GVHD, n (%) | NS | ||||
| I | 9 (28.1) | 17 (30.9) | 9 (27.3) | 52 (33.3) | |
| II | 6 (18.8) | 7 (12.7) | 7 (21.2) | 24 (15.4) | |
| III | 2 (6.3) | 2 (3.6) | 3 (9.1) | 10 (6.4) | |
| IV | 2 (6.3) | 2 (3.6) | 3 (9.1) | 2 (1.3) | |
| Relapse | 0 (0) | 4 (7.3) | 4 (12.1) | 23 (14.7) | .025 |
| TRM | 4 (12.5) | 10 (18.2) | 7 (21.2) | 27 (17.3) | NS |