Associations between categorical PRSs and MM risk in 1813 patients and 8871 controls of AA
| PRS category . | European-weighted PRS* . | AA-weighted PRS1† . | AA-weighted PRS2‡ . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | PHet . | OR (95% CI) . | P . | PHet . | OR (95% CI) . | P . | PHet . | |
| 0%-10% | 0.70 (0.57-0.86) | 6.52 × 10−4 | .94 | 0.52 (0.41-0.65) | 1.49 × 10−8 | .90 | 0.48 (0.37-0.60) | 9.68 × 10−10 | .56 |
| 10%-25% | 0.78 (0.66-0.92) | 3.10 × 10−3 | .30 | 0.70 (0.59-0.84) | 7.16 × 10−5 | .01 | 0.72 (0.60-0.85) | 1.34 × 10−4 | .83 |
| 25%-75% (reference) | 1 | NA | NA | 1 | NA | NA | 1 | NA | NA |
| 75%-90% | 1.24 (1.07-1.43) | 3.71 × 10−3 | .78 | 1.36 (1.18-1.56) | 1.54 × 10−5 | .99 | 1.39 (1.21-1.60) | 2.76 × 10−6 | .80 |
| 90%-100% | 1.61 (1.38-1.88) | 1.41 × 10−9 | .31 | 1.66 (1.43-1.94) | 7.54 × 10−11 | .37 | 1.82 (1.56-2.11) | 9.43 × 10−15 | .65 |
| PRS category . | European-weighted PRS* . | AA-weighted PRS1† . | AA-weighted PRS2‡ . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) . | P . | PHet . | OR (95% CI) . | P . | PHet . | OR (95% CI) . | P . | PHet . | |
| 0%-10% | 0.70 (0.57-0.86) | 6.52 × 10−4 | .94 | 0.52 (0.41-0.65) | 1.49 × 10−8 | .90 | 0.48 (0.37-0.60) | 9.68 × 10−10 | .56 |
| 10%-25% | 0.78 (0.66-0.92) | 3.10 × 10−3 | .30 | 0.70 (0.59-0.84) | 7.16 × 10−5 | .01 | 0.72 (0.60-0.85) | 1.34 × 10−4 | .83 |
| 25%-75% (reference) | 1 | NA | NA | 1 | NA | NA | 1 | NA | NA |
| 75%-90% | 1.24 (1.07-1.43) | 3.71 × 10−3 | .78 | 1.36 (1.18-1.56) | 1.54 × 10−5 | .99 | 1.39 (1.21-1.60) | 2.76 × 10−6 | .80 |
| 90%-100% | 1.61 (1.38-1.88) | 1.41 × 10−9 | .31 | 1.66 (1.43-1.94) | 7.54 × 10−11 | .37 | 1.82 (1.56-2.11) | 9.43 × 10−15 | .65 |
ORs were adjusted for age, sex, and PCs 1-10, P values are Wald P values, and PHet are P values of heterogeneity in fixed-effect meta analyses.
NA, not applicable.
European-weighted PRSs were constructed using the known 22 index SNPs reported in EUR GWASs, and weights were from original EUR GWASs.
AA-weighted PRS1 were constructed using the known 22 index SNPs reported in EUR GWASs, and weights were from AA MM.
AA-weighted PRS2 were constructed using 14 index SNPs (weights from AA MM) and 8 better AA markers (weights from AA MM and adjusted for their “winner’s curse” using a Bayesian approach).