Table 3. CAC associated with PFS and OS... | American Society of Hematology

Table 3.

CAC associated with PFS and OS by univariate and multivariate Cox regression analyses (P < .01)

CAC*	Aberration	n (%)	S0016B: Univariate Cox analysis, n = 246			Multivariate Cox analysis,† n = 230
Location	Aberration	n (%)	P	HR	95% CI	P	HR	95% CI
PFS
17q	Gain	45 (18)	.0064	1.76	(1.17, 2.64)	.010	1.80	(1.15, 2.70)
OS
2p	Gain	60 (24)	.0024	2.35	(1.36, 4.08)	.010	2.20	(1.21, 3.93)
2q	Deletion	8 (3)	.0018	4.37	(1.74, 11.03)	.002	4.80	(1.77, 12.94)
8q	Deletion	9 (4)	.0001	5.40	(2.30, 12.67)	.000	5.50	(2.25, 13.69)
16p	Deletion	6 (2)	.0002	5.75	(2.28, 14.52)	.000	6.70	(2.52, 17.58)
17p	Deletion	23 (9)	.0024	2.91	(1.46, 5.80)	.003	3.00	(1.47, 6.31)
22q	Deletion	7 (3)	.0007	5.00	(1.98, 12.65)	.001	5.70	(2.07, 15.80)

CAC*	Aberration	n (%)	S0016B: Univariate Cox analysis, n = 246			Multivariate Cox analysis,† n = 230
Location	Aberration	n (%)	P	HR	95% CI	P	HR	95% CI
PFS
17q	Gain	45 (18)	.0064	1.76	(1.17, 2.64)	.010	1.80	(1.15, 2.70)
OS
2p	Gain	60 (24)	.0024	2.35	(1.36, 4.08)	.010	2.20	(1.21, 3.93)
2q	Deletion	8 (3)	.0018	4.37	(1.74, 11.03)	.002	4.80	(1.77, 12.94)
8q	Deletion	9 (4)	.0001	5.40	(2.30, 12.67)	.000	5.50	(2.25, 13.69)
16p	Deletion	6 (2)	.0002	5.75	(2.28, 14.52)	.000	6.70	(2.52, 17.58)
17p	Deletion	23 (9)	.0024	2.91	(1.46, 5.80)	.003	3.00	(1.47, 6.31)
22q	Deletion	7 (3)	.0007	5.00	(1.98, 12.65)	.001	5.70	(2.07, 15.80)

All CAC are larger than 1 Mb.

Multivariate Cox analysis was performed with clinical covariates, including bulky disease, FLIPI risk, serum β2M, and elevated LDH level.