SPP associated with PFS and OS by univariate and multivariate Cox analyses (P < .01)
| SPP . | Size, bp . | Aberration . | n (%) . | S0016B: Univariate Cox analysis, n = 246 . | Multivariate Cox analysis,* n = 230 . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Genomic coordinates [hg19] (cancer gene) . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | |||
| PFS | |||||||||
| chr1q:174 534 242-175 945 964 | 1 411 723 | Gain | 45 (18) | .0028 | 1.85 | (1.23, 2.76) | <.0001 | 2.40 | (1.54, 3.60) |
| chr1q:186 786 032-188 822 614 | 2 036 583 | Gain | 47 (19) | .0039 | 1.80 | (1.21, 2.68) | <.0001 | 2.40 | (1.55, 3.59) |
| chr1q:188 836 200-189 407 527 | 571 328 | Gain | 47 (19) | .0039 | 1.80 | (1.21, 2.68) | <.0001 | 2.40 | (1.55, 3.59) |
| chr1q:223 686 766-228 558 892 (H3F3A) | 4 872 127 | Gain | 44 (18) | .0078 | 1.74 | (1.16, 2.61) | .000 | 2.20 | (1.44, 3.38) |
| chr2p:58 350 532-58 999 505 | 648 974 | Gain | 48 (20) | .0021 | 1.87 | (1.26, 2.78) | .010 | 1.80 | (1.14, 2.68) |
| chr4q:190 151 131-190 915 650 | 764 520 | Deletion | 7 (3) | .0008 | 3.74 | (1.73, 8.06) | .000 | 4.70 | (2.12, 10.37) |
| chr9p:21 944 544-21 971 352 (CDKN2A) | 26 809 | Deletion | 17 (7) | <.0001 | 3.04 | (1.76, 5.23) | .000 | 3.20 | (1.78, 5.58) |
| chr9p:22 549 702-23 132 263 | 582 562 | Deletion | 8 (3) | .0029 | 3.53 | (1.54, 8.10) | .004 | 3.50 | (1.51, 8.28) |
| chr15q:60 573 491-61 048 578 | 475 088 | Deletion | 10 (4) | .0042 | 2.88 | (1.40, 5.95) | .0048 | 3.10 | (1.41, 6.84) |
| chr17q:61 872 037-62 042 841 (CD79B) | 170 805 | Gain | 42 (17) | .0098 | 1.73 | (1.14, 2.62) | .010 | 1.80 | (1.15, 2.74) |
| OS | |||||||||
| chr2p:58 350 532-58 999 505 | 648 974 | Gain | 48 (20) | .0006 | 2.69 | (1.53, 4.71) | .005 | 2.40 | (1.30, 4.40) |
| chr2p:59 846 982-60 471 823 | 624 842 | Gain | 54 (22) | .0013 | 2.49 | (1.43, 4.34) | .007 | 2.30 | (1.26, 4.16) |
| chr5q:106 531 735-112 728 044 (APC) | 5 554 932 | Deletion | 8 (3) | .0026 | 4.12 | (1.64, 10.37) | .000 | 7.00 | (2.62, 18.95) |
| chr8p:32 662 782-34 324 581 | 1 661 800 | Deletion | 9 (4) | .0025 | 4.15 | (1.65, 10.47) | .0058 | 3.80 | (1.47, 9.67) |
| chr16p:2 838 274-6 941 015 (CREBBP) | 3 760 316 | Deletion | 6 (2) | .0002 | 5.75 | (2.28, 14.52) | .000 | 6.70 | (2.52, 17.58) |
| chr17p:7 394 281-8 225 873 (TP53) | 831 593 | Deletion | 21 (9) | .0005 | 3.39 | (1.70, 6.76) | .0004 | 3.90 | (1.85, 8.31) |
| chr17p:18 250 455-18 915 374 | 664 920 | Deletion | 14 (6) | .0001 | 4.43 | (2.07, 9.47) | .0003 | 4.90 | (2.06, 11.81) |
| SPP . | Size, bp . | Aberration . | n (%) . | S0016B: Univariate Cox analysis, n = 246 . | Multivariate Cox analysis,* n = 230 . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Genomic coordinates [hg19] (cancer gene) . | P . | HR . | 95% CI . | P . | HR . | 95% CI . | |||
| PFS | |||||||||
| chr1q:174 534 242-175 945 964 | 1 411 723 | Gain | 45 (18) | .0028 | 1.85 | (1.23, 2.76) | <.0001 | 2.40 | (1.54, 3.60) |
| chr1q:186 786 032-188 822 614 | 2 036 583 | Gain | 47 (19) | .0039 | 1.80 | (1.21, 2.68) | <.0001 | 2.40 | (1.55, 3.59) |
| chr1q:188 836 200-189 407 527 | 571 328 | Gain | 47 (19) | .0039 | 1.80 | (1.21, 2.68) | <.0001 | 2.40 | (1.55, 3.59) |
| chr1q:223 686 766-228 558 892 (H3F3A) | 4 872 127 | Gain | 44 (18) | .0078 | 1.74 | (1.16, 2.61) | .000 | 2.20 | (1.44, 3.38) |
| chr2p:58 350 532-58 999 505 | 648 974 | Gain | 48 (20) | .0021 | 1.87 | (1.26, 2.78) | .010 | 1.80 | (1.14, 2.68) |
| chr4q:190 151 131-190 915 650 | 764 520 | Deletion | 7 (3) | .0008 | 3.74 | (1.73, 8.06) | .000 | 4.70 | (2.12, 10.37) |
| chr9p:21 944 544-21 971 352 (CDKN2A) | 26 809 | Deletion | 17 (7) | <.0001 | 3.04 | (1.76, 5.23) | .000 | 3.20 | (1.78, 5.58) |
| chr9p:22 549 702-23 132 263 | 582 562 | Deletion | 8 (3) | .0029 | 3.53 | (1.54, 8.10) | .004 | 3.50 | (1.51, 8.28) |
| chr15q:60 573 491-61 048 578 | 475 088 | Deletion | 10 (4) | .0042 | 2.88 | (1.40, 5.95) | .0048 | 3.10 | (1.41, 6.84) |
| chr17q:61 872 037-62 042 841 (CD79B) | 170 805 | Gain | 42 (17) | .0098 | 1.73 | (1.14, 2.62) | .010 | 1.80 | (1.15, 2.74) |
| OS | |||||||||
| chr2p:58 350 532-58 999 505 | 648 974 | Gain | 48 (20) | .0006 | 2.69 | (1.53, 4.71) | .005 | 2.40 | (1.30, 4.40) |
| chr2p:59 846 982-60 471 823 | 624 842 | Gain | 54 (22) | .0013 | 2.49 | (1.43, 4.34) | .007 | 2.30 | (1.26, 4.16) |
| chr5q:106 531 735-112 728 044 (APC) | 5 554 932 | Deletion | 8 (3) | .0026 | 4.12 | (1.64, 10.37) | .000 | 7.00 | (2.62, 18.95) |
| chr8p:32 662 782-34 324 581 | 1 661 800 | Deletion | 9 (4) | .0025 | 4.15 | (1.65, 10.47) | .0058 | 3.80 | (1.47, 9.67) |
| chr16p:2 838 274-6 941 015 (CREBBP) | 3 760 316 | Deletion | 6 (2) | .0002 | 5.75 | (2.28, 14.52) | .000 | 6.70 | (2.52, 17.58) |
| chr17p:7 394 281-8 225 873 (TP53) | 831 593 | Deletion | 21 (9) | .0005 | 3.39 | (1.70, 6.76) | .0004 | 3.90 | (1.85, 8.31) |
| chr17p:18 250 455-18 915 374 | 664 920 | Deletion | 14 (6) | .0001 | 4.43 | (2.07, 9.47) | .0003 | 4.90 | (2.06, 11.81) |
Multivariate Cox analysis was performed with clinical covariates, including bulky disease, FLIPI risk, serum β2M, and elevated LDH level.