Association between prognostic markers and genomic complexity
| Genomic location [hg19] . | Size, bp . | Aberration . | n (%) . | Median aberration count . | P* . | |
|---|---|---|---|---|---|---|
| Absent . | Present . | |||||
| PFS markers | ||||||
| chr1q:174 534 242-175 945 964 | 1 411 723 | Gain | 45 (18) | 7 | 16 | 1.07E-06 |
| chr1q:186 786 032-188 822 614 | 2 036 583 | Gain | 47 (19) | 7 | 16 | 4.99E-07 |
| chr1q:188 836 200-189 407 527 | 571 328 | Gain | 47 (19) | 7 | 16 | 4.99E-07 |
| chr1q:223 686 766-228 558 892 | 4 872 127 | Gain | 44 (18) | 7 | 16.5 | 1.02E-06 |
| chr2p:58 350 532-58 999 505 | 648 974 | Gain | 48 (20) | 7 | 14 | 1.24E-05 |
| chr4q:190 151 131-190 915 650 | 764 520 | Deletion | 7 (3) | 8 | 15 | N.S. |
| chr9p:21 944 544-21 971 352 | 26 809 | Deletion | 17 (7) | 8 | 17 | .01169 |
| chr9p:22 549 702-23 132 263 | 582 562 | Deletion | 8 (3) | 8 | 18 | .00634 |
| chr15q:60 573 491-61 048 578 | 475 088 | Deletion | 10 (4) | 8 | 14.5 | .02538 |
| 17q | >1 M | Gain | 45 (18) | 7 | 14 | 3.41E-05 |
| chr17q:61 872,037-62 042 841 | 170 805 | Gain | 42 (17) | 7 | 14 | 4.76E-05 |
| OS markers | ||||||
| 2p | >1 M | Gain | 60 (24) | 7 | 13.5 | 6.63E-07 |
| chr2p:58 350 532-58 999 505 | 648 974 | Gain | 48 (20) | 7 | 14 | 1.24E-05 |
| chr2p:59 846 982-60 471 823 | 624 842 | Gain | 54 (22) | 7 | 14 | 1.32E-06 |
| 2q | >1 M | Deletion | 8 (3) | 8 | 18.5 | 7.84E-03 |
| chr5q:106 531 735-112 728 044 | 5 554 932 | Deletion | 8 (3) | 8 | 7 | N.S. |
| chr8p:32 662 782-34 324 581 | 1 661 800 | Deletion | 9 (4) | 8 | 29 | .01362 |
| 8q | >1 M | Deletion | 9 (4) | 8 | 19 | .01323 |
| 17p | >1 M | Deletion | 23 (9) | 7 | 18 | 1.82E-04 |
| chr17p:7 394 281-8 225 873 | 831 593 | Deletion | 21 (9) | 7 | 18 | 4.96E-04 |
| chr17p:18 250 455-18 915 374 | 664 920 | Deletion | 14 (6) | 8 | 18 | 5.72E-03 |
| 16p | >1 M | Deletion | 6 (2) | 8 | 31.5 | .02373 |
| chr16p:2 838 274-6 941 015 | 3 760 316 | Deletion | 6 (2) | 8 | 31.5 | .02373 |
| 22q | >1 M | Deletion | 7 (3) | 8 | 23 | .01145 |
| Genomic location [hg19] . | Size, bp . | Aberration . | n (%) . | Median aberration count . | P* . | |
|---|---|---|---|---|---|---|
| Absent . | Present . | |||||
| PFS markers | ||||||
| chr1q:174 534 242-175 945 964 | 1 411 723 | Gain | 45 (18) | 7 | 16 | 1.07E-06 |
| chr1q:186 786 032-188 822 614 | 2 036 583 | Gain | 47 (19) | 7 | 16 | 4.99E-07 |
| chr1q:188 836 200-189 407 527 | 571 328 | Gain | 47 (19) | 7 | 16 | 4.99E-07 |
| chr1q:223 686 766-228 558 892 | 4 872 127 | Gain | 44 (18) | 7 | 16.5 | 1.02E-06 |
| chr2p:58 350 532-58 999 505 | 648 974 | Gain | 48 (20) | 7 | 14 | 1.24E-05 |
| chr4q:190 151 131-190 915 650 | 764 520 | Deletion | 7 (3) | 8 | 15 | N.S. |
| chr9p:21 944 544-21 971 352 | 26 809 | Deletion | 17 (7) | 8 | 17 | .01169 |
| chr9p:22 549 702-23 132 263 | 582 562 | Deletion | 8 (3) | 8 | 18 | .00634 |
| chr15q:60 573 491-61 048 578 | 475 088 | Deletion | 10 (4) | 8 | 14.5 | .02538 |
| 17q | >1 M | Gain | 45 (18) | 7 | 14 | 3.41E-05 |
| chr17q:61 872,037-62 042 841 | 170 805 | Gain | 42 (17) | 7 | 14 | 4.76E-05 |
| OS markers | ||||||
| 2p | >1 M | Gain | 60 (24) | 7 | 13.5 | 6.63E-07 |
| chr2p:58 350 532-58 999 505 | 648 974 | Gain | 48 (20) | 7 | 14 | 1.24E-05 |
| chr2p:59 846 982-60 471 823 | 624 842 | Gain | 54 (22) | 7 | 14 | 1.32E-06 |
| 2q | >1 M | Deletion | 8 (3) | 8 | 18.5 | 7.84E-03 |
| chr5q:106 531 735-112 728 044 | 5 554 932 | Deletion | 8 (3) | 8 | 7 | N.S. |
| chr8p:32 662 782-34 324 581 | 1 661 800 | Deletion | 9 (4) | 8 | 29 | .01362 |
| 8q | >1 M | Deletion | 9 (4) | 8 | 19 | .01323 |
| 17p | >1 M | Deletion | 23 (9) | 7 | 18 | 1.82E-04 |
| chr17p:7 394 281-8 225 873 | 831 593 | Deletion | 21 (9) | 7 | 18 | 4.96E-04 |
| chr17p:18 250 455-18 915 374 | 664 920 | Deletion | 14 (6) | 8 | 18 | 5.72E-03 |
| 16p | >1 M | Deletion | 6 (2) | 8 | 31.5 | .02373 |
| chr16p:2 838 274-6 941 015 | 3 760 316 | Deletion | 6 (2) | 8 | 31.5 | .02373 |
| 22q | >1 M | Deletion | 7 (3) | 8 | 23 | .01145 |
N.S., not significant.
Welch unequal variances Student t test.