Frequency of kinase fusions in Ph-like ALL
| Active 3′ gene . | Partner 5′ gene . | Total number . | Boer et al20 . | Imamura et al44 . | Roberts et al24 . | Roberts et al8 . | Reshmi et al45 . |
|---|---|---|---|---|---|---|---|
| ABL1 | CENPC | 1 | — | — | — | — | 1 |
| ETV6 | 7 | — | 1 | 2 | 2 | 2 | |
| FOXP1 | 1 | 1 | — | — | — | — | |
| LSM14A | 1 | — | — | — | — | 1 | |
| NUP153 | 1 | — | — | — | — | 1 | |
| NUP214 | 12 | — | — | 1 | 6 | 5 | |
| RANBP2 | 4 | — | — | — | 1 | 3 | |
| RCSD1 | 3 | — | — | 1 | 1 | 1 | |
| SFPQ | 1 | — | — | 1 | — | — | |
| SNX1 | 1 | — | 1 | — | — | — | |
| SNX2 | 2 | — | — | 1 | 1 | — | |
| ZMIZ1 | 7 | 1 | 1 | — | 2 | 3 | |
| ABL2 | PAG1 | 2 | — | — | 1 | 1 | — |
| RCSD1 | 8 | 1 | — | 2 | 3 | 2 | |
| ZC3HAV1 | 6 | — | — | 3 | 1 | 2 | |
| CSF1R | MEF2D | 1 | — | — | 1 | — | — |
| SSBP2 | 9 | 2 | — | — | 4 | 3 | |
| TBL1XR1 | 1 | — | — | — | — | 1 | |
| PDGFRA | FIP1L1 | 1 | — | — | 1 | — | — |
| PDGFRB | ATF7IP | 3 | — | 2 | — | — | 1 |
| EBF1 | 28 | 4 | 6 | 3 | 6 | 9 | |
| ETV6 | 1 | — | — | — | — | 1 | |
| SNX29 | 1 | — | — | 1 | — | — | |
| SSBP2 | 1 | — | — | — | 1 | — | |
| TNIP1 | 3 | — | — | — | — | 3 | |
| ZEB2 | 1 | — | — | — | 1 | — | |
| ZMYND8 | 1 | — | — | — | — | 1 | |
| JAK2 | ATF7IP | 3 | — | — | 2 | 1 | — |
| BCR | 7 | 1 | — | 1 | 2 | 3 | |
| EBF1 | 1 | — | — | — | 1 | — | |
| ETV6 | 3 | — | — | 1 | 1 | 1 | |
| OFD1 | 1 | — | 1 | — | — | — | |
| PAX5 | 19 | 3 | 1 | 5 | 6 | 4 | |
| PCM1 | 1 | — | — | — | — | 1 | |
| PPFIBP1 | 2 | — | — | 1 | 1 | — | |
| RFX3 | 1 | — | — | — | — | 1 | |
| SMU1 | 1 | — | — | 1 | — | — | |
| SSBP2 | 6 | — | — | 2 | 2 | 2 | |
| STRN3 | 1 | — | — | — | 1 | — | |
| TERF2 | 2 | 1 | — | — | 1 | — | |
| TPR | 1 | — | — | — | 1 | — | |
| USP25 | 1 | — | — | — | — | 1 | |
| ZNF274 | 1 | — | — | — | — | 1 | |
| ZNF340 | 1 | — | — | 1 | — | — | |
| EPOR | IGH | 29 | — | 3 | 8 | 7 | 11 |
| IGK | 3 | — | — | 1 | 2 | — | |
| THADA | 1 | — | — | 1 | — | — | |
| CRLF2 | IGH | 181 | — | 2 | 57 | 61 | 61 |
| P2RY8 | 149 | 8 | 10 | 22 | 45 | 64 | |
| Unknown | 41 | 4 | — | 20 | 17 | — | |
| BLNK | DNTT | 1 | — | — | 1 | — | — |
| CBL | KANK1 | 1 | — | — | 1 | — | — |
| DGKH | ZFAND3 | 1 | — | — | — | 1 | — |
| FLT3 | ZMYM2 | 1 | — | — | 1 | — | — |
| IL2RB | MYH9 | 1 | — | — | — | 1 | — |
| LYN | GATA2DA | 1 | — | — | — | — | 1 |
| NCOR1 | 1 | — | 1 | — | — | — | |
| NTRK3 | ETV6 | 3 | — | — | 1 | 1 | 1 |
| PTK2B | TMEM2 | 1 | — | — | 1 | — | — |
| TYK2 | MYB | 1 | — | — | — | 1 | — |
| SMARCA4 | 1 | — | — | 1 | — | — | |
| ZNF340 | 1 | — | — | 1 | — | — | |
| Total | 578 |
| Active 3′ gene . | Partner 5′ gene . | Total number . | Boer et al20 . | Imamura et al44 . | Roberts et al24 . | Roberts et al8 . | Reshmi et al45 . |
|---|---|---|---|---|---|---|---|
| ABL1 | CENPC | 1 | — | — | — | — | 1 |
| ETV6 | 7 | — | 1 | 2 | 2 | 2 | |
| FOXP1 | 1 | 1 | — | — | — | — | |
| LSM14A | 1 | — | — | — | — | 1 | |
| NUP153 | 1 | — | — | — | — | 1 | |
| NUP214 | 12 | — | — | 1 | 6 | 5 | |
| RANBP2 | 4 | — | — | — | 1 | 3 | |
| RCSD1 | 3 | — | — | 1 | 1 | 1 | |
| SFPQ | 1 | — | — | 1 | — | — | |
| SNX1 | 1 | — | 1 | — | — | — | |
| SNX2 | 2 | — | — | 1 | 1 | — | |
| ZMIZ1 | 7 | 1 | 1 | — | 2 | 3 | |
| ABL2 | PAG1 | 2 | — | — | 1 | 1 | — |
| RCSD1 | 8 | 1 | — | 2 | 3 | 2 | |
| ZC3HAV1 | 6 | — | — | 3 | 1 | 2 | |
| CSF1R | MEF2D | 1 | — | — | 1 | — | — |
| SSBP2 | 9 | 2 | — | — | 4 | 3 | |
| TBL1XR1 | 1 | — | — | — | — | 1 | |
| PDGFRA | FIP1L1 | 1 | — | — | 1 | — | — |
| PDGFRB | ATF7IP | 3 | — | 2 | — | — | 1 |
| EBF1 | 28 | 4 | 6 | 3 | 6 | 9 | |
| ETV6 | 1 | — | — | — | — | 1 | |
| SNX29 | 1 | — | — | 1 | — | — | |
| SSBP2 | 1 | — | — | — | 1 | — | |
| TNIP1 | 3 | — | — | — | — | 3 | |
| ZEB2 | 1 | — | — | — | 1 | — | |
| ZMYND8 | 1 | — | — | — | — | 1 | |
| JAK2 | ATF7IP | 3 | — | — | 2 | 1 | — |
| BCR | 7 | 1 | — | 1 | 2 | 3 | |
| EBF1 | 1 | — | — | — | 1 | — | |
| ETV6 | 3 | — | — | 1 | 1 | 1 | |
| OFD1 | 1 | — | 1 | — | — | — | |
| PAX5 | 19 | 3 | 1 | 5 | 6 | 4 | |
| PCM1 | 1 | — | — | — | — | 1 | |
| PPFIBP1 | 2 | — | — | 1 | 1 | — | |
| RFX3 | 1 | — | — | — | — | 1 | |
| SMU1 | 1 | — | — | 1 | — | — | |
| SSBP2 | 6 | — | — | 2 | 2 | 2 | |
| STRN3 | 1 | — | — | — | 1 | — | |
| TERF2 | 2 | 1 | — | — | 1 | — | |
| TPR | 1 | — | — | — | 1 | — | |
| USP25 | 1 | — | — | — | — | 1 | |
| ZNF274 | 1 | — | — | — | — | 1 | |
| ZNF340 | 1 | — | — | 1 | — | — | |
| EPOR | IGH | 29 | — | 3 | 8 | 7 | 11 |
| IGK | 3 | — | — | 1 | 2 | — | |
| THADA | 1 | — | — | 1 | — | — | |
| CRLF2 | IGH | 181 | — | 2 | 57 | 61 | 61 |
| P2RY8 | 149 | 8 | 10 | 22 | 45 | 64 | |
| Unknown | 41 | 4 | — | 20 | 17 | — | |
| BLNK | DNTT | 1 | — | — | 1 | — | — |
| CBL | KANK1 | 1 | — | — | 1 | — | — |
| DGKH | ZFAND3 | 1 | — | — | — | 1 | — |
| FLT3 | ZMYM2 | 1 | — | — | 1 | — | — |
| IL2RB | MYH9 | 1 | — | — | — | 1 | — |
| LYN | GATA2DA | 1 | — | — | — | — | 1 |
| NCOR1 | 1 | — | 1 | — | — | — | |
| NTRK3 | ETV6 | 3 | — | — | 1 | 1 | 1 |
| PTK2B | TMEM2 | 1 | — | — | 1 | — | — |
| TYK2 | MYB | 1 | — | — | — | 1 | — |
| SMARCA4 | 1 | — | — | 1 | — | — | |
| ZNF340 | 1 | — | — | 1 | — | — | |
| Total | 578 |
Data are summarized from 5 recent studies of 2506 pediatric and adult patients with B-ALL.