Comparison of novel functional imaging techniques for assessment and monitoring of response to therapy
| . | PET/CT . | Functional MRI . |
|---|---|---|
| Studies available to date | Results reproduced in large prospective independent studies | Results reproduced in independent series of patients, even if mainly retrospective and heterogeneous populations |
| Prognostic relevance | Predicts high risk of early progression for patients with residual FLs | Possesses the higher reliability for diffuse BM infiltration |
| Refines the prognosis of patients in conventionally defined CR | Demonstrated early changes during treatment | |
| Defines the imaging MRD-negative response category | ||
| Is complementary to BM cellular or molecular-based techniques | ||
| Contributes to define the sustained MRD-negative response category, associated with the best patient outcomes |
| . | PET/CT . | Functional MRI . |
|---|---|---|
| Studies available to date | Results reproduced in large prospective independent studies | Results reproduced in independent series of patients, even if mainly retrospective and heterogeneous populations |
| Prognostic relevance | Predicts high risk of early progression for patients with residual FLs | Possesses the higher reliability for diffuse BM infiltration |
| Refines the prognosis of patients in conventionally defined CR | Demonstrated early changes during treatment | |
| Defines the imaging MRD-negative response category | ||
| Is complementary to BM cellular or molecular-based techniques | ||
| Contributes to define the sustained MRD-negative response category, associated with the best patient outcomes |