Table 1. Distribution of genotypes at... | American Society of Hematology

Table 1.

Distribution of genotypes at weaning from a breeding to generate low-TF;FIX^−/−offspring

Sex	mTF	hTF	FIX	Expected, %	E14.5, n	E14.5 observed, %	E14.5 O/E, %	P1, n	P1 observed, %	P1 O/E, %	P21, n	P21 observed, %	P21 O/E, %
F	+/−	+/(+/−)	+/+	12.5	7	18.4	147	3	6.6	52	15	18.5	148
F	+/−	+/(+/−)	+/−	12.5	7	18.4	147	7	15.5	147	13	16.0	128
M	+/−	+/(+/−)	+/y	12.5	1	2.6	21	10	22.2	178	15	18.5	148
M	+/−	+/(+/−)	−/y	12.5	4	10.5	84	8	17.7	142	9	11.1	89
F	−/−	+/(+/−)	+/+	12.5	5	13.2	106	4	8.8	70	8	9.9	79
F	−/−	+/(+/−)	+/−	12.5	5	13.2	106	2	4.4	35	12	14.8	118
M	−/−	+/(+/−)	+/y	12.5	5	13.2	106	6*	13.3	106	9	11.1	89
M	−/−	+/(+/−)	−/y	12.5	4	10.5	84	5†	11.1	89	0	0	0‡
Total				100.0	38	100.0	—	45	100.0	—	81	100.0	—

Sex	mTF	hTF	FIX	Expected, %	E14.5, n	E14.5 observed, %	E14.5 O/E, %	P1, n	P1 observed, %	P1 O/E, %	P21, n	P21 observed, %	P21 O/E, %
F	+/−	+/(+/−)	+/+	12.5	7	18.4	147	3	6.6	52	15	18.5	148
F	+/−	+/(+/−)	+/−	12.5	7	18.4	147	7	15.5	147	13	16.0	128
M	+/−	+/(+/−)	+/y	12.5	1	2.6	21	10	22.2	178	15	18.5	148
M	+/−	+/(+/−)	−/y	12.5	4	10.5	84	8	17.7	142	9	11.1	89
F	−/−	+/(+/−)	+/+	12.5	5	13.2	106	4	8.8	70	8	9.9	79
F	−/−	+/(+/−)	+/−	12.5	5	13.2	106	2	4.4	35	12	14.8	118
M	−/−	+/(+/−)	+/y	12.5	5	13.2	106	6*	13.3	106	9	11.1	89
M	−/−	+/(+/−)	−/y	12.5	4	10.5	84	5†	11.1	89	0	0	0‡
Total				100.0	38	100.0	—	45	100.0	—	81	100.0	—

F, female; hTF^+/(+/−), hTF^+/− or hTF^+/+; M, male; O/E, observed/expected.

One of 6 dead.

Two of 5 dead.

P < .05 observed vs expected, 2-tailed Fisher’s exact test.