Table 3.

Multivariable analysis for factors that have an impact on EFS in patients who achieved MRD-negative CR, adjusted for HCT after CAR T-cell therapy as a time-dependent covariate

VariableMultivariable analysisP
HR95% CI
LDH prelymphodepletion (per 100 U/L increment) 1.39 1.11-1.73 .004 
Platelets prelymphodepletion (per 50 000/μL increment) 0.74 0.53-1.03 .069 
Fludarabine added to lymphodepletion 0.25 0.15-0.78 .003 
HCT after CAR T-cell therapy 0.39 0.13-1.15 .088 
VariableMultivariable analysisP
HR95% CI
LDH prelymphodepletion (per 100 U/L increment) 1.39 1.11-1.73 .004 
Platelets prelymphodepletion (per 50 000/μL increment) 0.74 0.53-1.03 .069 
Fludarabine added to lymphodepletion 0.25 0.15-0.78 .003 
HCT after CAR T-cell therapy 0.39 0.13-1.15 .088 
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