Definition of molecular response based on the IS; adopted from ELN guidelines and NCCN guidelines, which reasonably can be used in children
| Milestone, mo. . | Optimal response . | Warning . | Failure . |
|---|---|---|---|
| 3 | BCR-ABL1 <10% IS | BCR-ABL1 ≥10% IS | |
| 6 | BCR-ABL1 <1%* IS | BCR-ABL1 1-10% IS | BCR-ABL1 ≥10% IS |
| 12 | BCR-ABL1 <0.1% IS | BCR-ABL1 0.1-1% IS | BCR-ABL1 ≥1% IS |
| Milestone, mo. . | Optimal response . | Warning . | Failure . |
|---|---|---|---|
| 3 | BCR-ABL1 <10% IS | BCR-ABL1 ≥10% IS | |
| 6 | BCR-ABL1 <1%* IS | BCR-ABL1 1-10% IS | BCR-ABL1 ≥10% IS |
| 12 | BCR-ABL1 <0.1% IS | BCR-ABL1 0.1-1% IS | BCR-ABL1 ≥1% IS |
See Baccarani et al44,84 for ELN guidelines, and NCCN Clinical Practice Guidelines in Oncology42 for NCCN guidelines.
The NCCN guidelines define 1%-10% as optimal at 6 mo.