ISM: multivariate analyses of prognostic factors for PFS and OS (n = 187)*
| Prognostic factor . | PFS . | OS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age at diagnosis ≥55 y | NS | NT | ||
| sβ2M ≥ 2.5 µg/mL | 9.8 (2.6-36) | <.001 | NS | |
| LDH < 230 U/L | NS | NT | ||
| SAP > 140 U/L | NS | NS | ||
| A/R/D pathogenic mutations with allele frequency ≥ 30% | 4.2 (1.2-10) | .02 | 51.8 (4.1-647) | .002 |
| A/R/D pathogenic mutations | NS | NS | ||
| ≥1 pathogenic mutation other than KIT | NS | NS | ||
| KIT D816V allele frequency ≥ 1% in BM | 12.0 (1.3-108) | .02 | NS | |
| KIT D816V allele frequency ≥ 6% in PB | NS | NS | ||
| Multilineal involvement of BM hematopoiesis by KIT D816V | NS | NS | ||
| Prognostic factor . | PFS . | OS . | ||
|---|---|---|---|---|
| HR (95% CI) . | P . | HR (95% CI) . | P . | |
| Age at diagnosis ≥55 y | NS | NT | ||
| sβ2M ≥ 2.5 µg/mL | 9.8 (2.6-36) | <.001 | NS | |
| LDH < 230 U/L | NS | NT | ||
| SAP > 140 U/L | NS | NS | ||
| A/R/D pathogenic mutations with allele frequency ≥ 30% | 4.2 (1.2-10) | .02 | 51.8 (4.1-647) | .002 |
| A/R/D pathogenic mutations | NS | NS | ||
| ≥1 pathogenic mutation other than KIT | NS | NS | ||
| KIT D816V allele frequency ≥ 1% in BM | 12.0 (1.3-108) | .02 | NS | |
| KIT D816V allele frequency ≥ 6% in PB | NS | NS | ||
| Multilineal involvement of BM hematopoiesis by KIT D816V | NS | NS | ||
CI, confidence interval; HR, hazard ratio; LDH, lactate dehydrogenase; NS, not statistically significant; NT, not tested.
With the exception of PB KIT D816V allele frequency ≥ 6%, which was performed in only 96 cases.