TEAEs
| TEAEs, n (%) . | 1200 mg (n = 8) . | 1800 mg (n = 45) . | ||
|---|---|---|---|---|
| All grades . | Grade 3 or 4 . | All grades . | Grade 3 or 4 . | |
| >25% . | >1 patient . | >25% . | >1 patient . | |
| Hematologic | ||||
| Thrombocytopenia | 3 (37.5) | 1 (12.5) | 8 (17.8) | 3 (6.7) |
| Anemia | 2 (25.0) | 1 (12.5) | 15 (33.3) | 7 (15.6) |
| Neutropenia | 1 (12.5) | 1 (12.5) | 7 (15.6) | 3 (6.7) |
| Lymphopenia | 0 | 0 | 8 (17.8) | 5 (11.1) |
| Nonhematologic | ||||
| Upper respiratory tract infection | 3 (37.5) | 1 (12.5) | 12 (26.7) | 0 |
| Insomnia | 3 (37.5) | 0 | 5 (11.1) | 0 |
| Decreased appetite | 3 (37.5) | 0 | 3 (6.7) | 0 |
| Pyrexia | 2 (25.0) | 0 | 12 (26.7) | 0 |
| Diarrhea | 2 (25.0) | 0 | 12 (26.7) | 0 |
| Fatigue | 2 (25.0) | 2 (25.0) | 10 (22.2) | 1 (2.2) |
| Hypertension | 2 (25.0) | 2 (25.0) | 4 (8.9) | 4 (8.9) |
| Pneumonia | 1 (12.5) | 1 (12.5) | 4 (8.9) | 2 (4.4) |
| Hyponatremia | 0 | 0 | 2 (4.4) | 2 (4.4) |
| Respiratory syncytial virus infection | 0 | 0 | 2 (4.4) | 2 (4.4) |
| Device-related infection | 0 | 0 | 2 (4.4) | 2 (4.4) |
| TEAEs, n (%) . | 1200 mg (n = 8) . | 1800 mg (n = 45) . | ||
|---|---|---|---|---|
| All grades . | Grade 3 or 4 . | All grades . | Grade 3 or 4 . | |
| >25% . | >1 patient . | >25% . | >1 patient . | |
| Hematologic | ||||
| Thrombocytopenia | 3 (37.5) | 1 (12.5) | 8 (17.8) | 3 (6.7) |
| Anemia | 2 (25.0) | 1 (12.5) | 15 (33.3) | 7 (15.6) |
| Neutropenia | 1 (12.5) | 1 (12.5) | 7 (15.6) | 3 (6.7) |
| Lymphopenia | 0 | 0 | 8 (17.8) | 5 (11.1) |
| Nonhematologic | ||||
| Upper respiratory tract infection | 3 (37.5) | 1 (12.5) | 12 (26.7) | 0 |
| Insomnia | 3 (37.5) | 0 | 5 (11.1) | 0 |
| Decreased appetite | 3 (37.5) | 0 | 3 (6.7) | 0 |
| Pyrexia | 2 (25.0) | 0 | 12 (26.7) | 0 |
| Diarrhea | 2 (25.0) | 0 | 12 (26.7) | 0 |
| Fatigue | 2 (25.0) | 2 (25.0) | 10 (22.2) | 1 (2.2) |
| Hypertension | 2 (25.0) | 2 (25.0) | 4 (8.9) | 4 (8.9) |
| Pneumonia | 1 (12.5) | 1 (12.5) | 4 (8.9) | 2 (4.4) |
| Hyponatremia | 0 | 0 | 2 (4.4) | 2 (4.4) |
| Respiratory syncytial virus infection | 0 | 0 | 2 (4.4) | 2 (4.4) |
| Device-related infection | 0 | 0 | 2 (4.4) | 2 (4.4) |