Table 1.

Blood cell counts of mice lacking Scl, Lyl1, or both factors in megakaryocytes

WT (n = 6)Pf4Sclc-KO (n = 6)Lyl1-KO (n = 6)DKO (n = 6)
Hemoglobin, g/dL 14.57 ± 0.37 15.47 ± 0.37 15.33 ± 0.79 14.42 ± 0.30 
White cells ×109/L 9.91 ± 1.15 11.91 ± 0.95 12.72 ± 0.84 9.99 ± 0.75 
Platelets ×109/L 1147 ± 88 807 ± 31* 1194 ± 97 200 ± 15† 
MPV, fL 5.75 ± 0.18 6.58 ± 0.13† 5.5 ± 0.13 6.83 ± 0.16† 
WT (n = 6)Pf4Sclc-KO (n = 6)Lyl1-KO (n = 6)DKO (n = 6)
Hemoglobin, g/dL 14.57 ± 0.37 15.47 ± 0.37 15.33 ± 0.79 14.42 ± 0.30 
White cells ×109/L 9.91 ± 1.15 11.91 ± 0.95 12.72 ± 0.84 9.99 ± 0.75 
Platelets ×109/L 1147 ± 88 807 ± 31* 1194 ± 97 200 ± 15† 
MPV, fL 5.75 ± 0.18 6.58 ± 0.13† 5.5 ± 0.13 6.83 ± 0.16† 

Blood parameters obtained from 6- to 8-week-old mice. Values shown are the mean ± standard error of the mean. Analyzed by using ordinary one-way ANOVA with Tukey’s multiple comparison test.

fL, femtoliter; MPV, mean platelet volume.

*

P = .01 compared with WT mice.

†

P < .001 compared with WT mice.

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